Reconstruction of tissue and gene expression

Research output: Contribution to conferencePaper

Abstract

Cell-cell communication between multiple cell populations is believed to be important for the activation of many cellular functions. It has previously been reported that rat hepatocytes in a double layer co-culture system with human endothelial cells were able to maintain albumin expression for a prolonged period of time. This result suggests that essential functions of hepatocytes were maintained via communication with endothelial cells in this co-culture system. In order to analyze the hepatocyte gene expression profile of double-layered co-culture, we try to isolate cDNAs, which increase in this co-culture system, from a subtractive library constructed by suppression subtractive hybridization (SSH). The results indicate that the many hepatocyte functions are increased by layered with HUVEC.

Original languageEnglish
Pages5347-5348
Number of pages2
Publication statusPublished - 2006 Dec 1
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Keywords

  • Cell sheet
  • Co-culture
  • Gene expression
  • Re-construction of liver

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Taniguchi, A. (2006). Reconstruction of tissue and gene expression. 5347-5348. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.