Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis

Toru Ishikawa, Takafumi Ichida, Yasunobu Matsuda, Soichi Sugitani, Motoya Sugiyama, Takashi Kato, Hiroshi Miyazaki, Hitoshi Asakura

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

It is widely accepted that thrombocytopenia associated with liver cirrhosis is caused by increased platelet destruction in the enlarged spleen, but this issue has not yet been analysed sufficiently in terms of platelet production. Thrombopoietin is produced mainly in the liver and strongly promotes platelet production. We studied serum thrombopoietin and the levels of its mRNA in liver tissue of cirrhotic patients and also in a rat model of liver cirrhosis. Furthermore, to clarify the influence of the spleen, we investigated thrombopoietin mRNA in splenectomized rats. The serum thrombopoietin level in humans with liver cirrhosis was not significantly reduced instead of thrombocytopenia. The expression of thrombopoietin mRNA in liver tissue decreased with the progression of liver cirrhosis in both patients and the rat model and no compensatory expression was observed in other organs or nonparenchymal cells. The level of thrombopoietin mRNA did not differ significantly in splenectomized cirrhotic rats before or after administration of dimethylnitrosamine, but was lower than that in splenectomized rats without cirrhosis. We conclude that thrombocytopenia in liver cirrhosis is caused not only by platelet destruction but also by decreased platelet production, perhaps due to reduction of thrombopoietin mRNA in the liver.

Original languageEnglish
Pages (from-to)907-913
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume13
Issue number9
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Thrombopoietin
Liver Cirrhosis
Thrombocytopenia
Blood Platelets
Messenger RNA
Liver
Dimethylnitrosamine
Splenomegaly
Serum
Fibrosis
Spleen

Keywords

  • Liver cirrhosis
  • Splenectomy
  • Thrombocytopenia
  • Thrombopoietin

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Ishikawa, T., Ichida, T., Matsuda, Y., Sugitani, S., Sugiyama, M., Kato, T., ... Asakura, H. (1998). Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis. Journal of Gastroenterology and Hepatology (Australia), 13(9), 907-913.

Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis. / Ishikawa, Toru; Ichida, Takafumi; Matsuda, Yasunobu; Sugitani, Soichi; Sugiyama, Motoya; Kato, Takashi; Miyazaki, Hiroshi; Asakura, Hitoshi.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 13, No. 9, 1998, p. 907-913.

Research output: Contribution to journalArticle

Ishikawa, T, Ichida, T, Matsuda, Y, Sugitani, S, Sugiyama, M, Kato, T, Miyazaki, H & Asakura, H 1998, 'Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis', Journal of Gastroenterology and Hepatology (Australia), vol. 13, no. 9, pp. 907-913.
Ishikawa, Toru ; Ichida, Takafumi ; Matsuda, Yasunobu ; Sugitani, Soichi ; Sugiyama, Motoya ; Kato, Takashi ; Miyazaki, Hiroshi ; Asakura, Hitoshi. / Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis. In: Journal of Gastroenterology and Hepatology (Australia). 1998 ; Vol. 13, No. 9. pp. 907-913.
@article{40ed7bb9ae0d4d9f87ddbf41d2b2b7b3,
title = "Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis",
abstract = "It is widely accepted that thrombocytopenia associated with liver cirrhosis is caused by increased platelet destruction in the enlarged spleen, but this issue has not yet been analysed sufficiently in terms of platelet production. Thrombopoietin is produced mainly in the liver and strongly promotes platelet production. We studied serum thrombopoietin and the levels of its mRNA in liver tissue of cirrhotic patients and also in a rat model of liver cirrhosis. Furthermore, to clarify the influence of the spleen, we investigated thrombopoietin mRNA in splenectomized rats. The serum thrombopoietin level in humans with liver cirrhosis was not significantly reduced instead of thrombocytopenia. The expression of thrombopoietin mRNA in liver tissue decreased with the progression of liver cirrhosis in both patients and the rat model and no compensatory expression was observed in other organs or nonparenchymal cells. The level of thrombopoietin mRNA did not differ significantly in splenectomized cirrhotic rats before or after administration of dimethylnitrosamine, but was lower than that in splenectomized rats without cirrhosis. We conclude that thrombocytopenia in liver cirrhosis is caused not only by platelet destruction but also by decreased platelet production, perhaps due to reduction of thrombopoietin mRNA in the liver.",
keywords = "Liver cirrhosis, Splenectomy, Thrombocytopenia, Thrombopoietin",
author = "Toru Ishikawa and Takafumi Ichida and Yasunobu Matsuda and Soichi Sugitani and Motoya Sugiyama and Takashi Kato and Hiroshi Miyazaki and Hitoshi Asakura",
year = "1998",
language = "English",
volume = "13",
pages = "907--913",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis

AU - Ishikawa, Toru

AU - Ichida, Takafumi

AU - Matsuda, Yasunobu

AU - Sugitani, Soichi

AU - Sugiyama, Motoya

AU - Kato, Takashi

AU - Miyazaki, Hiroshi

AU - Asakura, Hitoshi

PY - 1998

Y1 - 1998

N2 - It is widely accepted that thrombocytopenia associated with liver cirrhosis is caused by increased platelet destruction in the enlarged spleen, but this issue has not yet been analysed sufficiently in terms of platelet production. Thrombopoietin is produced mainly in the liver and strongly promotes platelet production. We studied serum thrombopoietin and the levels of its mRNA in liver tissue of cirrhotic patients and also in a rat model of liver cirrhosis. Furthermore, to clarify the influence of the spleen, we investigated thrombopoietin mRNA in splenectomized rats. The serum thrombopoietin level in humans with liver cirrhosis was not significantly reduced instead of thrombocytopenia. The expression of thrombopoietin mRNA in liver tissue decreased with the progression of liver cirrhosis in both patients and the rat model and no compensatory expression was observed in other organs or nonparenchymal cells. The level of thrombopoietin mRNA did not differ significantly in splenectomized cirrhotic rats before or after administration of dimethylnitrosamine, but was lower than that in splenectomized rats without cirrhosis. We conclude that thrombocytopenia in liver cirrhosis is caused not only by platelet destruction but also by decreased platelet production, perhaps due to reduction of thrombopoietin mRNA in the liver.

AB - It is widely accepted that thrombocytopenia associated with liver cirrhosis is caused by increased platelet destruction in the enlarged spleen, but this issue has not yet been analysed sufficiently in terms of platelet production. Thrombopoietin is produced mainly in the liver and strongly promotes platelet production. We studied serum thrombopoietin and the levels of its mRNA in liver tissue of cirrhotic patients and also in a rat model of liver cirrhosis. Furthermore, to clarify the influence of the spleen, we investigated thrombopoietin mRNA in splenectomized rats. The serum thrombopoietin level in humans with liver cirrhosis was not significantly reduced instead of thrombocytopenia. The expression of thrombopoietin mRNA in liver tissue decreased with the progression of liver cirrhosis in both patients and the rat model and no compensatory expression was observed in other organs or nonparenchymal cells. The level of thrombopoietin mRNA did not differ significantly in splenectomized cirrhotic rats before or after administration of dimethylnitrosamine, but was lower than that in splenectomized rats without cirrhosis. We conclude that thrombocytopenia in liver cirrhosis is caused not only by platelet destruction but also by decreased platelet production, perhaps due to reduction of thrombopoietin mRNA in the liver.

KW - Liver cirrhosis

KW - Splenectomy

KW - Thrombocytopenia

KW - Thrombopoietin

UR - http://www.scopus.com/inward/record.url?scp=0031720994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031720994&partnerID=8YFLogxK

M3 - Article

VL - 13

SP - 907

EP - 913

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 9

ER -