Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10

Michihiro Kon, Kai Tanabe, Takayuki Akimoto, Fuminori Kimura, Yuko Tanimura, Kazuhiro Shimizu, Tadashi Okamoto, Ichiro Kono

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Intensive physical exercise may cause muscular injury and increase oxidative stress. The purpose of this study was to examine the effect of an antioxidant, coenzyme Q10 (CoQ10), on muscular injury and oxidative stress during exercise training. Eighteen male students, all elite Japanese kendo athletes, were randomly assigned to either a CoQ10 group (n 10) or a placebo group (n 8) in a double-blind manner. Subjects in the CoQ10 group took 300 mg CoQ10 per d for 20 d, while subjects in the placebo group took the same dosage of a placebo. All subjects practised kendo 5.5 h per d for 6 d during the experimental period. Blood samples were taken 2 weeks before, during (1 d, 3 d, 5 d) and 1 week after the training. Serum creatine kinase (CK) activity and myoglobin (Mb) concentration significantly increased in both groups (at 3 d and 5 d). Serum CK (at 3 d), Mb (at 3 d) and lipid peroxide (at 3 d and 5 d) of the CoQ10 group were lower than those of the placebo group. The leucocyte counts in the placebo group significantly increased (at 3 d) and neutrophils significantly increased in both groups (at 3 d and 5 d). Serum scavenging activity against superoxide anion did not change in either group. These results indicate that CoQ10 supplementation reduced exercise-induced muscular injury in athletes.

Original languageEnglish
Pages (from-to)903-909
Number of pages7
JournalBritish Journal of Nutrition
Volume100
Issue number4
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

coenzyme Q10
Athletes
Placebos
Exercise
Wounds and Injuries
Myoglobin
Creatine Kinase
Oxidative Stress
Serum
Lipid Peroxides
Leukocyte Count
Superoxides
Neutrophils
Antioxidants
Students

Keywords

  • Coenzyme Q
  • Kendo
  • Muscular injury
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. / Kon, Michihiro; Tanabe, Kai; Akimoto, Takayuki; Kimura, Fuminori; Tanimura, Yuko; Shimizu, Kazuhiro; Okamoto, Tadashi; Kono, Ichiro.

In: British Journal of Nutrition, Vol. 100, No. 4, 2008, p. 903-909.

Research output: Contribution to journalArticle

Kon, M, Tanabe, K, Akimoto, T, Kimura, F, Tanimura, Y, Shimizu, K, Okamoto, T & Kono, I 2008, 'Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10', British Journal of Nutrition, vol. 100, no. 4, pp. 903-909. https://doi.org/10.1017/S0007114508926544
Kon, Michihiro ; Tanabe, Kai ; Akimoto, Takayuki ; Kimura, Fuminori ; Tanimura, Yuko ; Shimizu, Kazuhiro ; Okamoto, Tadashi ; Kono, Ichiro. / Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. In: British Journal of Nutrition. 2008 ; Vol. 100, No. 4. pp. 903-909.
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