Reduction of surface roughness of a laminin-apatite composite coating via inhibitory effect of magnesium ions on apatite crystal growth

Ayako Oyane, Yuusuke Ishikawa, Atsushi Yamazaki, Yu Sogo, Katsuko Furukawa, Takashi Ushida, Atsuo Ito

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    An artificial material coated with a laminin-apatite composite layer on its surface would be useful as a percutaneous device with cell-adhesion properties and good biocompatibility. The present authors recently prepared such a composite by a liquid-phase coating process in which a surface-modified material was immersed in a laminin-containing calcium phosphate solution (LCP solution) supersaturated with respect to apatite. As a result of this coating process, however, the material increased in surface roughness, which may have an adverse effect on the prevention of bacterial infection. In the present study, a reduction of the surface roughness of the laminin-apatite composite layer was attempted by adding MgSO4 to the LCP solution as an inhibitor of apatite crystal growth. The surface roughness, Ra, of the resulting laminin-apatite composite layer decreased from approximately 0.43 to 0.31 μm upon increasing the MgSO4 concentration in the LCP solution from 0 to 1.5 mM, while retaining its cell adhesion characteristics. The thus-obtained material, having a laminin-apatite composite coating with reduced surface roughness, has potential as a material for percutaneous devices with improved resistance to bacterial infection through the interface between the device and the skin.

    Original languageEnglish
    Pages (from-to)1342-1348
    Number of pages7
    JournalActa Biomaterialia
    Volume4
    Issue number5
    DOIs
    Publication statusPublished - 2008 Sep

    Fingerprint

    Apatites
    Composite coatings
    Apatite
    Laminin
    Crystallization
    Crystal growth
    Magnesium
    Surface roughness
    Ions
    Calcium phosphate
    Cell adhesion
    Composite materials
    Bacterial Infections
    Cell Adhesion
    Equipment and Supplies
    Coated materials
    Coatings
    Biocompatibility
    Skin
    Liquids

    Keywords

    • Apatite
    • Inhibitory effect
    • Laminin
    • Magnesium
    • Percutaneous device

    ASJC Scopus subject areas

    • Biomaterials
    • Biomedical Engineering
    • Biotechnology
    • Biochemistry
    • Molecular Biology

    Cite this

    Reduction of surface roughness of a laminin-apatite composite coating via inhibitory effect of magnesium ions on apatite crystal growth. / Oyane, Ayako; Ishikawa, Yuusuke; Yamazaki, Atsushi; Sogo, Yu; Furukawa, Katsuko; Ushida, Takashi; Ito, Atsuo.

    In: Acta Biomaterialia, Vol. 4, No. 5, 09.2008, p. 1342-1348.

    Research output: Contribution to journalArticle

    Oyane, Ayako ; Ishikawa, Yuusuke ; Yamazaki, Atsushi ; Sogo, Yu ; Furukawa, Katsuko ; Ushida, Takashi ; Ito, Atsuo. / Reduction of surface roughness of a laminin-apatite composite coating via inhibitory effect of magnesium ions on apatite crystal growth. In: Acta Biomaterialia. 2008 ; Vol. 4, No. 5. pp. 1342-1348.
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