Reelin and cyclin-dependent kinase 5

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Reelin, an extracellular signaling molecule, and cyclin-dependent kinase 5 (Cdk5), a cytoplasmic kinase, are key regulators of normal brain development, including establishment of the complex brain structure. Recent studies have indicated that both Reelin signaling and Cdk5 are also involved in synaptic plasticity and neurodegeneration. In this chapter, I shall describe the functions of Cdk5 in neuronal migration during brain development and present an overview of the relationship of Cdk5 with Reelin signaling based on analyses of mutant mouse models. I shall also refer to the functions of Reelin signaling and Cdk5 in dendrite development, synaptic plasticity, and neurodegeneration.

    Original languageEnglish
    Title of host publicationReelin Glycoprotein: Structure, Biology and Roles in Health and Disease
    PublisherSpringer New York
    Pages127-139
    Number of pages13
    ISBN (Print)9780387767611, 9780387767604
    DOIs
    Publication statusPublished - 2008

    Fingerprint

    Cyclin-Dependent Kinase 5
    Neuronal Plasticity
    Brain
    Dendrites
    Phosphotransferases

    ASJC Scopus subject areas

    • Medicine(all)
    • Neuroscience(all)

    Cite this

    Ohshima, T. (2008). Reelin and cyclin-dependent kinase 5. In Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease (pp. 127-139). Springer New York. https://doi.org/10.1007/978-0-387-76761-1_9

    Reelin and cyclin-dependent kinase 5. / Ohshima, Toshio.

    Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. Springer New York, 2008. p. 127-139.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Ohshima, T 2008, Reelin and cyclin-dependent kinase 5. in Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. Springer New York, pp. 127-139. https://doi.org/10.1007/978-0-387-76761-1_9
    Ohshima T. Reelin and cyclin-dependent kinase 5. In Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. Springer New York. 2008. p. 127-139 https://doi.org/10.1007/978-0-387-76761-1_9
    Ohshima, Toshio. / Reelin and cyclin-dependent kinase 5. Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. Springer New York, 2008. pp. 127-139
    @inbook{7c2d8507937e419ea322ecabbec1907b,
    title = "Reelin and cyclin-dependent kinase 5",
    abstract = "Reelin, an extracellular signaling molecule, and cyclin-dependent kinase 5 (Cdk5), a cytoplasmic kinase, are key regulators of normal brain development, including establishment of the complex brain structure. Recent studies have indicated that both Reelin signaling and Cdk5 are also involved in synaptic plasticity and neurodegeneration. In this chapter, I shall describe the functions of Cdk5 in neuronal migration during brain development and present an overview of the relationship of Cdk5 with Reelin signaling based on analyses of mutant mouse models. I shall also refer to the functions of Reelin signaling and Cdk5 in dendrite development, synaptic plasticity, and neurodegeneration.",
    author = "Toshio Ohshima",
    year = "2008",
    doi = "10.1007/978-0-387-76761-1_9",
    language = "English",
    isbn = "9780387767611",
    pages = "127--139",
    booktitle = "Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease",
    publisher = "Springer New York",

    }

    TY - CHAP

    T1 - Reelin and cyclin-dependent kinase 5

    AU - Ohshima, Toshio

    PY - 2008

    Y1 - 2008

    N2 - Reelin, an extracellular signaling molecule, and cyclin-dependent kinase 5 (Cdk5), a cytoplasmic kinase, are key regulators of normal brain development, including establishment of the complex brain structure. Recent studies have indicated that both Reelin signaling and Cdk5 are also involved in synaptic plasticity and neurodegeneration. In this chapter, I shall describe the functions of Cdk5 in neuronal migration during brain development and present an overview of the relationship of Cdk5 with Reelin signaling based on analyses of mutant mouse models. I shall also refer to the functions of Reelin signaling and Cdk5 in dendrite development, synaptic plasticity, and neurodegeneration.

    AB - Reelin, an extracellular signaling molecule, and cyclin-dependent kinase 5 (Cdk5), a cytoplasmic kinase, are key regulators of normal brain development, including establishment of the complex brain structure. Recent studies have indicated that both Reelin signaling and Cdk5 are also involved in synaptic plasticity and neurodegeneration. In this chapter, I shall describe the functions of Cdk5 in neuronal migration during brain development and present an overview of the relationship of Cdk5 with Reelin signaling based on analyses of mutant mouse models. I shall also refer to the functions of Reelin signaling and Cdk5 in dendrite development, synaptic plasticity, and neurodegeneration.

    UR - http://www.scopus.com/inward/record.url?scp=84920046608&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84920046608&partnerID=8YFLogxK

    U2 - 10.1007/978-0-387-76761-1_9

    DO - 10.1007/978-0-387-76761-1_9

    M3 - Chapter

    AN - SCOPUS:84920046608

    SN - 9780387767611

    SN - 9780387767604

    SP - 127

    EP - 139

    BT - Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease

    PB - Springer New York

    ER -