Reelin, an extracellular signaling molecule, and cyclin-dependent kinase 5 (Cdk5), a cytoplasmic kinase, are key regulators of normal brain development, including establishment of the complex brain structure. Recent studies have indicated that both Reelin signaling and Cdk5 are also involved in synaptic plasticity and neurodegeneration. In this chapter, I shall describe the functions of Cdk5 in neuronal migration during brain development and present an overview of the relationship of Cdk5 with Reelin signaling based on analyses of mutant mouse models. I shall also refer to the functions of Reelin signaling and Cdk5 in dendrite development, synaptic plasticity, and neurodegeneration.
|Title of host publication||Reelin Glycoprotein|
|Subtitle of host publication||Structure, Biology and Roles in Health and Disease|
|Publisher||Springer New York|
|Number of pages||13|
|Publication status||Published - 2008 Jan 1|
ASJC Scopus subject areas