Reelin signaling and Cdk5 in the control of neuronal positioning

Toshio Ohshima, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Neuronal positioning is important for higher brain function because it is the architectural basis of the formation of precise synaptic circuits. Analysis of neurological mutant mice has led to dramatic progress in the identification and characterization of molecules important for neuronal positioning in the developing mammalian brain. Among these molecules, identification of signal pathways mediated by Reelin and Cdk5 kinase has provided a conceptual framework for exploring the molecular mechanisms underlying proper neuronal positioning in the developing mammalian brain. Recent evidence has implicated synergism between Reelin signaling and Cdk5 in contributing to the proper positioning of selective neuronal populations.

Original languageEnglish
Pages (from-to)153-166
Number of pages14
JournalMolecular Neurobiology
Volume26
Issue number2-3
DOIs
Publication statusPublished - 2002 Oct
Externally publishedYes

Fingerprint

Brain
Neurologic Mutant Mice
Signal Transduction
Phosphotransferases
Population

Keywords

  • ApoER2
  • Cajal-Retzius cell
  • Cdk5
  • CNR
  • CR-50
  • Dab1
  • p35
  • p39
  • Reelin
  • VLDLR

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Reelin signaling and Cdk5 in the control of neuronal positioning. / Ohshima, Toshio; Mikoshiba, Katsuhiko.

In: Molecular Neurobiology, Vol. 26, No. 2-3, 10.2002, p. 153-166.

Research output: Contribution to journalArticle

Ohshima, Toshio ; Mikoshiba, Katsuhiko. / Reelin signaling and Cdk5 in the control of neuronal positioning. In: Molecular Neurobiology. 2002 ; Vol. 26, No. 2-3. pp. 153-166.
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