Regional differences in the vascular response to CO2 among cerebral, ocular, and mesenteric vessels

A. Miyaji, T. Ikemura, Y. Hamada, N. Hayashi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: It is well-known that cerebral and ocular vessels are highly sensitive to changes in the partial pressure of CO2 (PETCO2). However, it is unclear whether there are regional differences in the magnitude of the vascular response to CO2 (CO2 reactivity) in various vessels of a single individual, and whether there is a relationship in the CO2 reactivity of specific vessels between different individuals. Methods: We compared the CO2 reactivity of the superior mesenteric artery (SMA), middle cerebral artery (MCA), retinal artery (RA), and retinal and choroidal vessels (RCV) during a 3-min inhalation of CO2-rich air (5%) in 70 subjects. Results: The blood flow velocities in the MCA, RA, and RCV significantly increased by 21±2% (mean±SE), 9±1%, and 7±2%, respectively (P2 reactivity-the relative change in blood flow to a given change in PETCO2-was significantly greater in the MCA (2.2±0.2%/mmHg) than in the RA and RCV (0.9±0.1%/mmHg and 0.8±0.2%/mmHg, respectively). There was a weak correlation in the CO2 reactivity only between RA and RCV (r=0.43, P2 reactivity can vary even in cerebral and ocular vessels, although the correlation is weak.

Original languageEnglish
JournalArtery Research
DOIs
Publication statusAccepted/In press - 2015 Jul 15

Fingerprint

Retinal Artery
Retinal Vessels
Blood Vessels
Middle Cerebral Artery
Superior Mesenteric Artery
Blood Flow Velocity
Partial Pressure
Inhalation
Air

Keywords

  • Cerebral circulation
  • CO<inf>2</inf> reactivity
  • Endothelial function
  • Ocular circulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anatomy
  • Physiology (medical)

Cite this

Regional differences in the vascular response to CO2 among cerebral, ocular, and mesenteric vessels. / Miyaji, A.; Ikemura, T.; Hamada, Y.; Hayashi, N.

In: Artery Research, 15.07.2015.

Research output: Contribution to journalArticle

@article{ee8afbfe0922485b950da363f0e8f04c,
title = "Regional differences in the vascular response to CO2 among cerebral, ocular, and mesenteric vessels",
abstract = "Background: It is well-known that cerebral and ocular vessels are highly sensitive to changes in the partial pressure of CO2 (PETCO2). However, it is unclear whether there are regional differences in the magnitude of the vascular response to CO2 (CO2 reactivity) in various vessels of a single individual, and whether there is a relationship in the CO2 reactivity of specific vessels between different individuals. Methods: We compared the CO2 reactivity of the superior mesenteric artery (SMA), middle cerebral artery (MCA), retinal artery (RA), and retinal and choroidal vessels (RCV) during a 3-min inhalation of CO2-rich air (5{\%}) in 70 subjects. Results: The blood flow velocities in the MCA, RA, and RCV significantly increased by 21±2{\%} (mean±SE), 9±1{\%}, and 7±2{\%}, respectively (P2 reactivity-the relative change in blood flow to a given change in PETCO2-was significantly greater in the MCA (2.2±0.2{\%}/mmHg) than in the RA and RCV (0.9±0.1{\%}/mmHg and 0.8±0.2{\%}/mmHg, respectively). There was a weak correlation in the CO2 reactivity only between RA and RCV (r=0.43, P2 reactivity can vary even in cerebral and ocular vessels, although the correlation is weak.",
keywords = "Cerebral circulation, CO<inf>2</inf> reactivity, Endothelial function, Ocular circulation",
author = "A. Miyaji and T. Ikemura and Y. Hamada and N. Hayashi",
year = "2015",
month = "7",
day = "15",
doi = "10.1016/j.artres.2015.08.001",
language = "English",
journal = "Artery Research",
issn = "1872-9312",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Regional differences in the vascular response to CO2 among cerebral, ocular, and mesenteric vessels

AU - Miyaji, A.

AU - Ikemura, T.

AU - Hamada, Y.

AU - Hayashi, N.

PY - 2015/7/15

Y1 - 2015/7/15

N2 - Background: It is well-known that cerebral and ocular vessels are highly sensitive to changes in the partial pressure of CO2 (PETCO2). However, it is unclear whether there are regional differences in the magnitude of the vascular response to CO2 (CO2 reactivity) in various vessels of a single individual, and whether there is a relationship in the CO2 reactivity of specific vessels between different individuals. Methods: We compared the CO2 reactivity of the superior mesenteric artery (SMA), middle cerebral artery (MCA), retinal artery (RA), and retinal and choroidal vessels (RCV) during a 3-min inhalation of CO2-rich air (5%) in 70 subjects. Results: The blood flow velocities in the MCA, RA, and RCV significantly increased by 21±2% (mean±SE), 9±1%, and 7±2%, respectively (P2 reactivity-the relative change in blood flow to a given change in PETCO2-was significantly greater in the MCA (2.2±0.2%/mmHg) than in the RA and RCV (0.9±0.1%/mmHg and 0.8±0.2%/mmHg, respectively). There was a weak correlation in the CO2 reactivity only between RA and RCV (r=0.43, P2 reactivity can vary even in cerebral and ocular vessels, although the correlation is weak.

AB - Background: It is well-known that cerebral and ocular vessels are highly sensitive to changes in the partial pressure of CO2 (PETCO2). However, it is unclear whether there are regional differences in the magnitude of the vascular response to CO2 (CO2 reactivity) in various vessels of a single individual, and whether there is a relationship in the CO2 reactivity of specific vessels between different individuals. Methods: We compared the CO2 reactivity of the superior mesenteric artery (SMA), middle cerebral artery (MCA), retinal artery (RA), and retinal and choroidal vessels (RCV) during a 3-min inhalation of CO2-rich air (5%) in 70 subjects. Results: The blood flow velocities in the MCA, RA, and RCV significantly increased by 21±2% (mean±SE), 9±1%, and 7±2%, respectively (P2 reactivity-the relative change in blood flow to a given change in PETCO2-was significantly greater in the MCA (2.2±0.2%/mmHg) than in the RA and RCV (0.9±0.1%/mmHg and 0.8±0.2%/mmHg, respectively). There was a weak correlation in the CO2 reactivity only between RA and RCV (r=0.43, P2 reactivity can vary even in cerebral and ocular vessels, although the correlation is weak.

KW - Cerebral circulation

KW - CO<inf>2</inf> reactivity

KW - Endothelial function

KW - Ocular circulation

UR - http://www.scopus.com/inward/record.url?scp=84940843169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940843169&partnerID=8YFLogxK

U2 - 10.1016/j.artres.2015.08.001

DO - 10.1016/j.artres.2015.08.001

M3 - Article

AN - SCOPUS:84940843169

JO - Artery Research

JF - Artery Research

SN - 1872-9312

ER -