Regions of unusually high flexibility occur frequently in human genomic DNA

Hajime Kimura, Dai Kageyama, Mika Furuya, Shigeru Sugiyama, Noboru Murata, Takashi Ohyama*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Remarkable progress has been made in genome science during the past decade, but understanding of genomes of eukaryotes is far from complete. We have created DNA flexibility maps of the human, mouse, fruit fly, and nematode chromosomes. The maps revealed that all of these chromosomes have markedly flexible DNA regions (We named them SPIKEs). SPIKEs occur more frequently in the human chromosomes than in the mouse, fruit fly, and nematode chromosomes. Markedly rigid DNA regions (rSPIKEs) are also present in these chromosomes. The ratio of the number of SPIKEs to the total number of SPIKEs and rSPIKEs correlated positively with evolutionary stage among the organisms. Repetitive DNA sequences with flexible and rigid properties contribute to the formation of SPIKEs and rSPIKEs respectively. However, non-repetitive flexible and rigid sequences appear to play a major role in SPIKE and rSPIKE formation respectively. They might be involved in the genome-folding mechanism of eukaryotes.

Original languageEnglish
Pages (from-to)612-617
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Issue number3
Publication statusPublished - 2013


  • Eukaryotic genome
  • Flexibility map
  • Genome evolution
  • Genome folding
  • Repetitive DNA

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


Dive into the research topics of 'Regions of unusually high flexibility occur frequently in human genomic DNA'. Together they form a unique fingerprint.

Cite this