Regioselective synthesis of piceatannol from resveratrol: Catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells

Toshiki Furuya, Kuniki Kino

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    Piceatannol, a valuable biologically active stilbene derivative, was efficiently synthesized from resveratrol. Whole-cell catalysis with HpaBC monooxygenase enabled the regioselective hydroxylation of resveratrol to produce 23 mM (5.2 g L-1) of piceatannol.

    Original languageEnglish
    Pages (from-to)2853-2855
    Number of pages3
    JournalTetrahedron Letters
    Volume55
    Issue number17
    DOIs
    Publication statusPublished - 2014 Apr 23

    Fingerprint

    Mixed Function Oxygenases
    Catalysis
    Stilbenes
    Hydroxylation
    Derivatives
    resveratrol
    3,3',4,5'-tetrahydroxystilbene
    4,6-dinitro-o-cresol

    Keywords

    • HpaBC
    • Hydroxylation
    • Monooxygenase
    • Piceatannol

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    Cite this

    Regioselective synthesis of piceatannol from resveratrol : Catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells. / Furuya, Toshiki; Kino, Kuniki.

    In: Tetrahedron Letters, Vol. 55, No. 17, 23.04.2014, p. 2853-2855.

    Research output: Contribution to journalArticle

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