Regioselective synthesis of piceatannol from resveratrol: Catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells

Toshiki Furuya, Kuniki Kino

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Piceatannol, a valuable biologically active stilbene derivative, was efficiently synthesized from resveratrol. Whole-cell catalysis with HpaBC monooxygenase enabled the regioselective hydroxylation of resveratrol to produce 23 mM (5.2 g L-1) of piceatannol.

Original languageEnglish
Pages (from-to)2853-2855
Number of pages3
JournalTetrahedron Letters
Volume55
Issue number17
DOIs
Publication statusPublished - 2014 Apr 23

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Keywords

  • HpaBC
  • Hydroxylation
  • Monooxygenase
  • Piceatannol

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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