Regular exercise improves cognitive function and decreases oxidative damage in rat brain

Zsolt Radák*, Takao Kaneko, Shoichi Tahara, Hideko Nakamoto, Jozsef Pucsok, Mária Sasvári, Csaba Nyakas, Sataro Goto

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

309 Citations (Scopus)


The biochemical mechanisms by which regular exercise significantly benefits health and well being, including improved cognitive function, are not well understood. Four-week-old (young) and 14-month-old (middle aged) Wistar rats were randomly assigned to young control and young exercised, middle-aged control and middle-aged exercised groups. Exercise groups were exposed to a swimming regime of 1 h a day, 5 days a week for 9 weeks. The passive avoidance test showed that middle-aged exercised rats had significantly (P<0.05) better short- (24 h) and long-term (72 h) memory than aged-matched control rats. Conditioned pole-jumping avoidance learning was improved markedly in both age groups by exercise. Brain thiobarbituric acid-reactive substances and 8-hydroxy-2'deoxyguanosine content in the DNA did not change significantly, while the protein carbonyl levels decreased significantly (P<0.05) in both exercised groups. This decrease was accompanied by an increase in the chymotrypsin-like activity of proteasome complex in the exercised groups, whereas trypsin-like activity did not differ significantly between all groups. The DT-diaphorase activity increased significantly (P<0.05) in the brain of young exercised animals. These data show that swimming training improves some cognitive functions in rats, with parallel attenuation of the accumulation of oxidatively damaged proteins. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalNeurochemistry International
Issue number1
Publication statusPublished - 2001 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology


Dive into the research topics of 'Regular exercise improves cognitive function and decreases oxidative damage in rat brain'. Together they form a unique fingerprint.

Cite this