Regular exercise improves cognitive function and decreases oxidative damage in rat brain

Zsolt Radak, Takao Kaneko, Shoichi Tahara, Hideko Nakamoto, Jozsef Pucsok, Mária Sasvári, Csaba Nyakas, Sataro Goto

Research output: Contribution to journalArticle

264 Citations (Scopus)

Abstract

The biochemical mechanisms by which regular exercise significantly benefits health and well being, including improved cognitive function, are not well understood. Four-week-old (young) and 14-month-old (middle aged) Wistar rats were randomly assigned to young control and young exercised, middle-aged control and middle-aged exercised groups. Exercise groups were exposed to a swimming regime of 1 h a day, 5 days a week for 9 weeks. The passive avoidance test showed that middle-aged exercised rats had significantly (P<0.05) better short- (24 h) and long-term (72 h) memory than aged-matched control rats. Conditioned pole-jumping avoidance learning was improved markedly in both age groups by exercise. Brain thiobarbituric acid-reactive substances and 8-hydroxy-2'deoxyguanosine content in the DNA did not change significantly, while the protein carbonyl levels decreased significantly (P<0.05) in both exercised groups. This decrease was accompanied by an increase in the chymotrypsin-like activity of proteasome complex in the exercised groups, whereas trypsin-like activity did not differ significantly between all groups. The DT-diaphorase activity increased significantly (P<0.05) in the brain of young exercised animals. These data show that swimming training improves some cognitive functions in rats, with parallel attenuation of the accumulation of oxidatively damaged proteins. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalNeurochemistry International
Volume38
Issue number1
DOIs
Publication statusPublished - 2001 Jan 1
Externally publishedYes

Fingerprint

Cognition
Exercise
Brain
NAD(P)H Dehydrogenase (Quinone)
Avoidance Learning
Thiobarbituric Acid Reactive Substances
Chymotrypsin
Insurance Benefits
Proteasome Endopeptidase Complex
Trypsin
Wistar Rats
Proteins
Age Groups
DNA
8-oxo-7-hydrodeoxyguanosine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Regular exercise improves cognitive function and decreases oxidative damage in rat brain. / Radak, Zsolt; Kaneko, Takao; Tahara, Shoichi; Nakamoto, Hideko; Pucsok, Jozsef; Sasvári, Mária; Nyakas, Csaba; Goto, Sataro.

In: Neurochemistry International, Vol. 38, No. 1, 01.01.2001, p. 17-23.

Research output: Contribution to journalArticle

Radak, Z, Kaneko, T, Tahara, S, Nakamoto, H, Pucsok, J, Sasvári, M, Nyakas, C & Goto, S 2001, 'Regular exercise improves cognitive function and decreases oxidative damage in rat brain', Neurochemistry International, vol. 38, no. 1, pp. 17-23. https://doi.org/10.1016/S0197-0186(00)00063-2
Radak, Zsolt ; Kaneko, Takao ; Tahara, Shoichi ; Nakamoto, Hideko ; Pucsok, Jozsef ; Sasvári, Mária ; Nyakas, Csaba ; Goto, Sataro. / Regular exercise improves cognitive function and decreases oxidative damage in rat brain. In: Neurochemistry International. 2001 ; Vol. 38, No. 1. pp. 17-23.
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