Regulation of chromatin structure by curved DNA: How activator binding sites become accessible

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A single somatic cell of humans contains DNA fibers of a total length of approximately 2 m, which are compacted, without entanglement, into the nucleus of approximately 1×10-5 m in diameter. To greater or lesser degrees, all organisms compact their DNA. Biologically important DNA regions, such as the origins of DNA replication, regulatory regions of transcription, and recombination loci, must all be compacted. The tightly constrained DNA, however, presents the appropriate environment for replication, transcription, and recombination to take place.

Original languageEnglish
Title of host publicationNuclear Dynamics
Subtitle of host publicationMolecular Biology and Visualization of the Nucleus
PublisherSpringer Japan
Pages227-238
Number of pages12
ISBN (Electronic)9784431301301
ISBN (Print)4431300546, 9784431300540
DOIs
Publication statusPublished - 2007 Jan 1

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ohyama, T. (2007). Regulation of chromatin structure by curved DNA: How activator binding sites become accessible. In Nuclear Dynamics: Molecular Biology and Visualization of the Nucleus (pp. 227-238). Springer Japan. https://doi.org/10.1007/978-4-431-30130-1_10