Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones

Kohtaro Takei, Ryong Moon Shin, Takafumi Inoue, Kunio Kato, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) acts as a Ca2+ release channel on internal Ca2+ stores. Type 1 IP3R(IP3R1) is enriched in growth cones of neurons in chick dorsal root ganglia. Depletion of internal Ca2+ stores and inhibition of IP3 signaling with drugs inhibited neurite extension. Microinjection of heparin, a competitive IP3R blocker, induced neurite retraction. Acute localized loss of function of IP3R1 in the growth cone induced by chromophore-assisted laser inactivation resulted in growth arrest and neurite retraction. IP3-induced Ca2+ release in growth cones appears to have a crucial role in control of nerve growth.

Original languageEnglish
Pages (from-to)1705-1708
Number of pages4
JournalScience
Volume282
Issue number5394
Publication statusPublished - 1998 Nov 27
Externally publishedYes

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Inositol 1,4,5-Trisphosphate Receptors
Growth Cones
Neurites
Chromophore-Assisted Light Inactivation
Growth
Inositol 1,4,5-Trisphosphate
Microinjections
Spinal Ganglia
Heparin
Neurons
Pharmaceutical Preparations

ASJC Scopus subject areas

  • General

Cite this

Takei, K., Shin, R. M., Inoue, T., Kato, K., & Mikoshiba, K. (1998). Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones. Science, 282(5394), 1705-1708.

Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones. / Takei, Kohtaro; Shin, Ryong Moon; Inoue, Takafumi; Kato, Kunio; Mikoshiba, Katsuhiko.

In: Science, Vol. 282, No. 5394, 27.11.1998, p. 1705-1708.

Research output: Contribution to journalArticle

Takei, K, Shin, RM, Inoue, T, Kato, K & Mikoshiba, K 1998, 'Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones', Science, vol. 282, no. 5394, pp. 1705-1708.
Takei K, Shin RM, Inoue T, Kato K, Mikoshiba K. Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones. Science. 1998 Nov 27;282(5394):1705-1708.
Takei, Kohtaro ; Shin, Ryong Moon ; Inoue, Takafumi ; Kato, Kunio ; Mikoshiba, Katsuhiko. / Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones. In: Science. 1998 ; Vol. 282, No. 5394. pp. 1705-1708.
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