TY - JOUR
T1 - Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones
AU - Takei, Kohtaro
AU - Shin, Ryong Moon
AU - Inoue, Takafumi
AU - Kato, Kunio
AU - Mikoshiba, Katsuhiko
PY - 1998/11/27
Y1 - 1998/11/27
N2 - The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) acts as a Ca2+ release channel on internal Ca2+ stores. Type 1 IP3R(IP3R1) is enriched in growth cones of neurons in chick dorsal root ganglia. Depletion of internal Ca2+ stores and inhibition of IP3 signaling with drugs inhibited neurite extension. Microinjection of heparin, a competitive IP3R blocker, induced neurite retraction. Acute localized loss of function of IP3R1 in the growth cone induced by chromophore-assisted laser inactivation resulted in growth arrest and neurite retraction. IP3-induced Ca2+ release in growth cones appears to have a crucial role in control of nerve growth.
AB - The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) acts as a Ca2+ release channel on internal Ca2+ stores. Type 1 IP3R(IP3R1) is enriched in growth cones of neurons in chick dorsal root ganglia. Depletion of internal Ca2+ stores and inhibition of IP3 signaling with drugs inhibited neurite extension. Microinjection of heparin, a competitive IP3R blocker, induced neurite retraction. Acute localized loss of function of IP3R1 in the growth cone induced by chromophore-assisted laser inactivation resulted in growth arrest and neurite retraction. IP3-induced Ca2+ release in growth cones appears to have a crucial role in control of nerve growth.
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U2 - 10.1126/science.282.5394.1705
DO - 10.1126/science.282.5394.1705
M3 - Article
C2 - 9831561
AN - SCOPUS:0032573570
SN - 0036-8075
VL - 282
SP - 1705
EP - 1708
JO - Science
JF - Science
IS - 5394
ER -