Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones

Kohtaro Takei, Ryong Moon Shin, Takafumi Inoue, Kunio Kato, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) acts as a Ca2+ release channel on internal Ca2+ stores. Type 1 IP3R(IP3R1) is enriched in growth cones of neurons in chick dorsal root ganglia. Depletion of internal Ca2+ stores and inhibition of IP3 signaling with drugs inhibited neurite extension. Microinjection of heparin, a competitive IP3R blocker, induced neurite retraction. Acute localized loss of function of IP3R1 in the growth cone induced by chromophore-assisted laser inactivation resulted in growth arrest and neurite retraction. IP3-induced Ca2+ release in growth cones appears to have a crucial role in control of nerve growth.

Original languageEnglish
Pages (from-to)1705-1708
Number of pages4
JournalScience
Volume282
Issue number5394
DOIs
Publication statusPublished - 1998 Nov 27
Externally publishedYes

ASJC Scopus subject areas

  • General

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