Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides

Jean Luc Do Rego, Jae Young Seong, Delphine Burel, Jerôme Leprince, David Vaudry, Van Luu-The, Marie Christine Tonon, Kazuyoshi Tsutsui, Georges Pelletier, Hubert Vaudry

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    The enzymatic pathways leading to the synthesis of bioactive steroids in the brain are now almost completely elucidated in various groups of vertebrates and, during the last decade, the neuronal mechanisms involved in the regulation of neurosteroid production have received increasing attention. This report reviews the current knowledge concerning the effects of neurotransmitters, peptide hormones, and neuropeptides on the biosynthesis of neurosteroids. Anatomical studies have been carried out to visualize the neurotransmitteror neuropeptidecontaining fibers contacting steroidsynthesizing neurons as well as the neurotransmitter, peptide hormones, or neuropeptide receptors expressed in these neurons. Biochemical experiments have been conducted to investigate the effects of neurotransmitters, peptide hormones, or neuropeptides on neurosteroid biosynthesis, and to characterize the type of receptors involved. Thus, it has been found that glutamate, acting through kainate and/or AMPA receptors, rapidly inactivates P450arom, and that melatonin produced by the pineal gland and eye inhibits the biosynthesis of 7α-hydroxypregnenolone (7α-OH-Δ5P), while prolactin produced by the adenohypophysis enhances the formation of 7α-OH-Δ5P. It has also been demonstrated that the biosynthesis of neurosteroids is inhibited by GABA, acting through GABAA receptors, and neuropeptide Y, acting through Y1 receptors. In contrast, it has been shown that the octadecaneuropetide ODN, acting through centraltype benzodiazepine receptors, the triakontatetraneuropeptideTTN, acting though peripheraltype benzodiazepine receptors, and vasotocin, acting through V1alike receptors, stimulate the production of neurosteroids. Since neurosteroids are implicated in the control of various neurophysiological and behavioral processes, these data suggest that some of the neurophysiological effects exerted by neurotransmitters and neuropeptides may be mediated via the regulation of neurosteroid production.

    Original languageEnglish
    Article numberArticle 4
    JournalFrontiers in Endocrinology
    Volume3
    Issue numberJAN
    DOIs
    Publication statusPublished - 2012

    Fingerprint

    Neuropeptides
    Neurotransmitter Agents
    GABA-A Receptors
    Peptide Hormones
    Neuropeptide Receptors
    Vasotocin
    Kainic Acid Receptors
    Neurons
    Anterior Pituitary Gland
    Pineal Gland
    Peptide Receptors
    AMPA Receptors
    Neuropeptide Y
    Melatonin
    Prolactin
    gamma-Aminobutyric Acid
    Vertebrates
    Glutamic Acid
    Steroids

    Keywords

    • Endozepines
    • GABA
    • Glutamate
    • Melatonin
    • Neuropeptide Y
    • Neurosteroids
    • Prolactin
    • Vasopressin

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism

    Cite this

    Rego, J. L. D., Seong, J. Y., Burel, D., Leprince, J., Vaudry, D., Luu-The, V., ... Vaudry, H. (2012). Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. Frontiers in Endocrinology, 3(JAN), [Article 4]. https://doi.org/10.3389/fendo.2012.00004

    Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. / Rego, Jean Luc Do; Seong, Jae Young; Burel, Delphine; Leprince, Jerôme; Vaudry, David; Luu-The, Van; Tonon, Marie Christine; Tsutsui, Kazuyoshi; Pelletier, Georges; Vaudry, Hubert.

    In: Frontiers in Endocrinology, Vol. 3, No. JAN, Article 4, 2012.

    Research output: Contribution to journalArticle

    Rego, JLD, Seong, JY, Burel, D, Leprince, J, Vaudry, D, Luu-The, V, Tonon, MC, Tsutsui, K, Pelletier, G & Vaudry, H 2012, 'Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides', Frontiers in Endocrinology, vol. 3, no. JAN, Article 4. https://doi.org/10.3389/fendo.2012.00004
    Rego JLD, Seong JY, Burel D, Leprince J, Vaudry D, Luu-The V et al. Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. Frontiers in Endocrinology. 2012;3(JAN). Article 4. https://doi.org/10.3389/fendo.2012.00004
    Rego, Jean Luc Do ; Seong, Jae Young ; Burel, Delphine ; Leprince, Jerôme ; Vaudry, David ; Luu-The, Van ; Tonon, Marie Christine ; Tsutsui, Kazuyoshi ; Pelletier, Georges ; Vaudry, Hubert. / Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. In: Frontiers in Endocrinology. 2012 ; Vol. 3, No. JAN.
    @article{4dc385c0d76f4e44b3f492f9f00f2168,
    title = "Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides",
    abstract = "The enzymatic pathways leading to the synthesis of bioactive steroids in the brain are now almost completely elucidated in various groups of vertebrates and, during the last decade, the neuronal mechanisms involved in the regulation of neurosteroid production have received increasing attention. This report reviews the current knowledge concerning the effects of neurotransmitters, peptide hormones, and neuropeptides on the biosynthesis of neurosteroids. Anatomical studies have been carried out to visualize the neurotransmitteror neuropeptidecontaining fibers contacting steroidsynthesizing neurons as well as the neurotransmitter, peptide hormones, or neuropeptide receptors expressed in these neurons. Biochemical experiments have been conducted to investigate the effects of neurotransmitters, peptide hormones, or neuropeptides on neurosteroid biosynthesis, and to characterize the type of receptors involved. Thus, it has been found that glutamate, acting through kainate and/or AMPA receptors, rapidly inactivates P450arom, and that melatonin produced by the pineal gland and eye inhibits the biosynthesis of 7α-hydroxypregnenolone (7α-OH-Δ5P), while prolactin produced by the adenohypophysis enhances the formation of 7α-OH-Δ5P. It has also been demonstrated that the biosynthesis of neurosteroids is inhibited by GABA, acting through GABAA receptors, and neuropeptide Y, acting through Y1 receptors. In contrast, it has been shown that the octadecaneuropetide ODN, acting through centraltype benzodiazepine receptors, the triakontatetraneuropeptideTTN, acting though peripheraltype benzodiazepine receptors, and vasotocin, acting through V1alike receptors, stimulate the production of neurosteroids. Since neurosteroids are implicated in the control of various neurophysiological and behavioral processes, these data suggest that some of the neurophysiological effects exerted by neurotransmitters and neuropeptides may be mediated via the regulation of neurosteroid production.",
    keywords = "Endozepines, GABA, Glutamate, Melatonin, Neuropeptide Y, Neurosteroids, Prolactin, Vasopressin",
    author = "Rego, {Jean Luc Do} and Seong, {Jae Young} and Delphine Burel and Jer{\^o}me Leprince and David Vaudry and Van Luu-The and Tonon, {Marie Christine} and Kazuyoshi Tsutsui and Georges Pelletier and Hubert Vaudry",
    year = "2012",
    doi = "10.3389/fendo.2012.00004",
    language = "English",
    volume = "3",
    journal = "Frontiers in Endocrinology",
    issn = "1664-2392",
    publisher = "Frontiers Media S. A.",
    number = "JAN",

    }

    TY - JOUR

    T1 - Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides

    AU - Rego, Jean Luc Do

    AU - Seong, Jae Young

    AU - Burel, Delphine

    AU - Leprince, Jerôme

    AU - Vaudry, David

    AU - Luu-The, Van

    AU - Tonon, Marie Christine

    AU - Tsutsui, Kazuyoshi

    AU - Pelletier, Georges

    AU - Vaudry, Hubert

    PY - 2012

    Y1 - 2012

    N2 - The enzymatic pathways leading to the synthesis of bioactive steroids in the brain are now almost completely elucidated in various groups of vertebrates and, during the last decade, the neuronal mechanisms involved in the regulation of neurosteroid production have received increasing attention. This report reviews the current knowledge concerning the effects of neurotransmitters, peptide hormones, and neuropeptides on the biosynthesis of neurosteroids. Anatomical studies have been carried out to visualize the neurotransmitteror neuropeptidecontaining fibers contacting steroidsynthesizing neurons as well as the neurotransmitter, peptide hormones, or neuropeptide receptors expressed in these neurons. Biochemical experiments have been conducted to investigate the effects of neurotransmitters, peptide hormones, or neuropeptides on neurosteroid biosynthesis, and to characterize the type of receptors involved. Thus, it has been found that glutamate, acting through kainate and/or AMPA receptors, rapidly inactivates P450arom, and that melatonin produced by the pineal gland and eye inhibits the biosynthesis of 7α-hydroxypregnenolone (7α-OH-Δ5P), while prolactin produced by the adenohypophysis enhances the formation of 7α-OH-Δ5P. It has also been demonstrated that the biosynthesis of neurosteroids is inhibited by GABA, acting through GABAA receptors, and neuropeptide Y, acting through Y1 receptors. In contrast, it has been shown that the octadecaneuropetide ODN, acting through centraltype benzodiazepine receptors, the triakontatetraneuropeptideTTN, acting though peripheraltype benzodiazepine receptors, and vasotocin, acting through V1alike receptors, stimulate the production of neurosteroids. Since neurosteroids are implicated in the control of various neurophysiological and behavioral processes, these data suggest that some of the neurophysiological effects exerted by neurotransmitters and neuropeptides may be mediated via the regulation of neurosteroid production.

    AB - The enzymatic pathways leading to the synthesis of bioactive steroids in the brain are now almost completely elucidated in various groups of vertebrates and, during the last decade, the neuronal mechanisms involved in the regulation of neurosteroid production have received increasing attention. This report reviews the current knowledge concerning the effects of neurotransmitters, peptide hormones, and neuropeptides on the biosynthesis of neurosteroids. Anatomical studies have been carried out to visualize the neurotransmitteror neuropeptidecontaining fibers contacting steroidsynthesizing neurons as well as the neurotransmitter, peptide hormones, or neuropeptide receptors expressed in these neurons. Biochemical experiments have been conducted to investigate the effects of neurotransmitters, peptide hormones, or neuropeptides on neurosteroid biosynthesis, and to characterize the type of receptors involved. Thus, it has been found that glutamate, acting through kainate and/or AMPA receptors, rapidly inactivates P450arom, and that melatonin produced by the pineal gland and eye inhibits the biosynthesis of 7α-hydroxypregnenolone (7α-OH-Δ5P), while prolactin produced by the adenohypophysis enhances the formation of 7α-OH-Δ5P. It has also been demonstrated that the biosynthesis of neurosteroids is inhibited by GABA, acting through GABAA receptors, and neuropeptide Y, acting through Y1 receptors. In contrast, it has been shown that the octadecaneuropetide ODN, acting through centraltype benzodiazepine receptors, the triakontatetraneuropeptideTTN, acting though peripheraltype benzodiazepine receptors, and vasotocin, acting through V1alike receptors, stimulate the production of neurosteroids. Since neurosteroids are implicated in the control of various neurophysiological and behavioral processes, these data suggest that some of the neurophysiological effects exerted by neurotransmitters and neuropeptides may be mediated via the regulation of neurosteroid production.

    KW - Endozepines

    KW - GABA

    KW - Glutamate

    KW - Melatonin

    KW - Neuropeptide Y

    KW - Neurosteroids

    KW - Prolactin

    KW - Vasopressin

    UR - http://www.scopus.com/inward/record.url?scp=84874434434&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84874434434&partnerID=8YFLogxK

    U2 - 10.3389/fendo.2012.00004

    DO - 10.3389/fendo.2012.00004

    M3 - Article

    C2 - 22654849

    AN - SCOPUS:84874434434

    VL - 3

    JO - Frontiers in Endocrinology

    JF - Frontiers in Endocrinology

    SN - 1664-2392

    IS - JAN

    M1 - Article 4

    ER -