Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2

Kageumi Takeno, Yoshifumi Tamura, Minako Kawaguchi, Saori Kakehi, Takahiro Watanabe, Takashi Funayama, Yasuhiko Furukawa, Hideyoshi Kaga, Risako Yamamoto, Maengkyu Kim, Miho Nishitani-Yokoyama, Kazunori Shimada, Hiroyuki Daida, Shigeki Aoki, Hikari Taka, Tsutomu Fujimura, Susumu Sawada, Adria Giacca, Akio Kanazawa, Yoshio Fujitani & 2 others Ryuzo Kawamori, Hirotaka Watada

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Context: Although metabolic abnormalities are often developed in Asians with body mass index (BMI) of 23-25 kg/m2, the characteristics of the nonobese Asians with metabolic abnormality have not been fully understood. Objective: The aim of this study was to investigate the clinical significance of insulin sensitivity in Japanese men with BMI of 23-25 kg/m2. Design and Participants: In this study, we defined hypertension, hyperglycemia, and dyslipidemia as cardiometabolic risk factors (CMRFs). We recruited subjects who met the following selection criteria: men with BMI of 21-23 kg/m2 and no CMRF (n = 24); men with BMI of 23-25 kg/m2 and no CMRF (n = 28), or one CMRF (n = 28), or at least two CMRFs (n = 14); and overweight men with metabolic syndrome (n = 20). Insulin sensitivity (IS) and ectopic fat content in muscle and liver were measured by two-step hyperinsulinemic-euglycemic clamp and 1H-magnetic resonance spectroscopy, respectively. Results: Among subjects with BMI of 23-25 kg/m2, impaired IS in muscle, but not in liver, was found in those with even one CMRF, whereas impaired IS in both muscle and liver was observed in overweight men with metabolic syndrome. Liver fat accumulation and elevated liver enzymes were associated with impaired IS in both muscle and liver in those subjects. Conclusions: Among Japanese men with BMI of 23-25 kg/m2, muscle insulin resistance was present in those with even one CMRF. In this population, liver fat accumulation and/or elevated liver enzymes could be a good marker for impaired IS in both muscle and liver.

Original languageEnglish
Pages (from-to)3676-3684
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume101
Issue number10
DOIs
Publication statusPublished - 2016 Oct 1
Externally publishedYes

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Liver
Insulin Resistance
Body Mass Index
Insulin
Muscle
Muscles
Fats
Magnetic resonance spectroscopy
Glucose Clamp Technique
Clamping devices
Enzymes
Dyslipidemias
Hyperglycemia
Patient Selection
Magnetic Resonance Spectroscopy
Hypertension
Population

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2 . / Takeno, Kageumi; Tamura, Yoshifumi; Kawaguchi, Minako; Kakehi, Saori; Watanabe, Takahiro; Funayama, Takashi; Furukawa, Yasuhiko; Kaga, Hideyoshi; Yamamoto, Risako; Kim, Maengkyu; Nishitani-Yokoyama, Miho; Shimada, Kazunori; Daida, Hiroyuki; Aoki, Shigeki; Taka, Hikari; Fujimura, Tsutomu; Sawada, Susumu; Giacca, Adria; Kanazawa, Akio; Fujitani, Yoshio; Kawamori, Ryuzo; Watada, Hirotaka.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 101, No. 10, 01.10.2016, p. 3676-3684.

Research output: Contribution to journalArticle

Takeno, K, Tamura, Y, Kawaguchi, M, Kakehi, S, Watanabe, T, Funayama, T, Furukawa, Y, Kaga, H, Yamamoto, R, Kim, M, Nishitani-Yokoyama, M, Shimada, K, Daida, H, Aoki, S, Taka, H, Fujimura, T, Sawada, S, Giacca, A, Kanazawa, A, Fujitani, Y, Kawamori, R & Watada, H 2016, 'Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2 ', Journal of Clinical Endocrinology and Metabolism, vol. 101, no. 10, pp. 3676-3684. https://doi.org/10.1210/jc.2016-1650
Takeno, Kageumi ; Tamura, Yoshifumi ; Kawaguchi, Minako ; Kakehi, Saori ; Watanabe, Takahiro ; Funayama, Takashi ; Furukawa, Yasuhiko ; Kaga, Hideyoshi ; Yamamoto, Risako ; Kim, Maengkyu ; Nishitani-Yokoyama, Miho ; Shimada, Kazunori ; Daida, Hiroyuki ; Aoki, Shigeki ; Taka, Hikari ; Fujimura, Tsutomu ; Sawada, Susumu ; Giacca, Adria ; Kanazawa, Akio ; Fujitani, Yoshio ; Kawamori, Ryuzo ; Watada, Hirotaka. / Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2 In: Journal of Clinical Endocrinology and Metabolism. 2016 ; Vol. 101, No. 10. pp. 3676-3684.
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abstract = "Context: Although metabolic abnormalities are often developed in Asians with body mass index (BMI) of 23-25 kg/m2, the characteristics of the nonobese Asians with metabolic abnormality have not been fully understood. Objective: The aim of this study was to investigate the clinical significance of insulin sensitivity in Japanese men with BMI of 23-25 kg/m2. Design and Participants: In this study, we defined hypertension, hyperglycemia, and dyslipidemia as cardiometabolic risk factors (CMRFs). We recruited subjects who met the following selection criteria: men with BMI of 21-23 kg/m2 and no CMRF (n = 24); men with BMI of 23-25 kg/m2 and no CMRF (n = 28), or one CMRF (n = 28), or at least two CMRFs (n = 14); and overweight men with metabolic syndrome (n = 20). Insulin sensitivity (IS) and ectopic fat content in muscle and liver were measured by two-step hyperinsulinemic-euglycemic clamp and 1H-magnetic resonance spectroscopy, respectively. Results: Among subjects with BMI of 23-25 kg/m2, impaired IS in muscle, but not in liver, was found in those with even one CMRF, whereas impaired IS in both muscle and liver was observed in overweight men with metabolic syndrome. Liver fat accumulation and elevated liver enzymes were associated with impaired IS in both muscle and liver in those subjects. Conclusions: Among Japanese men with BMI of 23-25 kg/m2, muscle insulin resistance was present in those with even one CMRF. In this population, liver fat accumulation and/or elevated liver enzymes could be a good marker for impaired IS in both muscle and liver.",
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T1 - Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2

AU - Takeno, Kageumi

AU - Tamura, Yoshifumi

AU - Kawaguchi, Minako

AU - Kakehi, Saori

AU - Watanabe, Takahiro

AU - Funayama, Takashi

AU - Furukawa, Yasuhiko

AU - Kaga, Hideyoshi

AU - Yamamoto, Risako

AU - Kim, Maengkyu

AU - Nishitani-Yokoyama, Miho

AU - Shimada, Kazunori

AU - Daida, Hiroyuki

AU - Aoki, Shigeki

AU - Taka, Hikari

AU - Fujimura, Tsutomu

AU - Sawada, Susumu

AU - Giacca, Adria

AU - Kanazawa, Akio

AU - Fujitani, Yoshio

AU - Kawamori, Ryuzo

AU - Watada, Hirotaka

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Context: Although metabolic abnormalities are often developed in Asians with body mass index (BMI) of 23-25 kg/m2, the characteristics of the nonobese Asians with metabolic abnormality have not been fully understood. Objective: The aim of this study was to investigate the clinical significance of insulin sensitivity in Japanese men with BMI of 23-25 kg/m2. Design and Participants: In this study, we defined hypertension, hyperglycemia, and dyslipidemia as cardiometabolic risk factors (CMRFs). We recruited subjects who met the following selection criteria: men with BMI of 21-23 kg/m2 and no CMRF (n = 24); men with BMI of 23-25 kg/m2 and no CMRF (n = 28), or one CMRF (n = 28), or at least two CMRFs (n = 14); and overweight men with metabolic syndrome (n = 20). Insulin sensitivity (IS) and ectopic fat content in muscle and liver were measured by two-step hyperinsulinemic-euglycemic clamp and 1H-magnetic resonance spectroscopy, respectively. Results: Among subjects with BMI of 23-25 kg/m2, impaired IS in muscle, but not in liver, was found in those with even one CMRF, whereas impaired IS in both muscle and liver was observed in overweight men with metabolic syndrome. Liver fat accumulation and elevated liver enzymes were associated with impaired IS in both muscle and liver in those subjects. Conclusions: Among Japanese men with BMI of 23-25 kg/m2, muscle insulin resistance was present in those with even one CMRF. In this population, liver fat accumulation and/or elevated liver enzymes could be a good marker for impaired IS in both muscle and liver.

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DO - 10.1210/jc.2016-1650

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SP - 3676

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