Relation between VE/VCO2 slope and maximum phonation time in chronic heart failure patients

Kazuhiro P. Izawa*, Satoshi Watanabe, Peter H. Brubaker, Shinobu Tochimoto, Yasuyuki Hirano, Shinya Matsushima, Tomohiro Suzuki, Koichiro Oka, Takashi Saito, Yutaka Omori, Kengo Suzuki, Naohiko Osada, Kazuto Omiya, Hiroyuki Shimizu, Yoshihiro J. Akashi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


This study aimed to determine the relation between the regression slope relating minute ventilation to carbon dioxide output (VE/VCO2 slope) and maximum phonation time (MPT), and the MPT required to attain a threshold value for VE/VCO2 slope of ≤34 in chronic heart failure (CHF) patients. This cross-sectional study enrolled 115 CHF patients (mean age, 54.5 years; men, 84.9%). VE/VCO2 slope was assessed during cardiopulmonary exercise testing (CPX). Thereafter, patients were divided into 2 groups according to exercise capacity: VE/VCO2 slope ≤34 (VE/VCO2 ≤34 group, n = 81) and VE/VCO2 slope >34 (VE/VCO2 >34 group, n = 34). For MPT measurements, all patients produced a sustained vowel/a:/ for as long as possible during respiratory effort from the seated position. All subjects showed significant negative correlation between VE/VCO2 slope and MPT (r = -0.51, P < 0.001). After adjustment for clinical characteristics, MPT was significantly higher in the VE/VCO2 ≤34 group vs VE/VCO2 >34 group (21.4 ± 6.4 vs 17.4 ± 4.3 s, F = 7.4, P = 0.007). The appropriate MPT cut-off value for identifying a VE/VCO2 slope ≤34 was 18.12 seconds. An MPT value of 18.12 seconds may be a useful target value for identifying CHF patients with a VE/VCO2 slope ≤34 and for risk management in these patients.

Original languageEnglish
Pages (from-to)e306
JournalMedicine (United States)
Issue number29
Publication statusPublished - 2014 Dec 13

ASJC Scopus subject areas

  • Medicine(all)


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