TY - JOUR
T1 - Relationship between cardiorespiratory fitness and non-high-density lipoprotein cholesterol
T2 - A cohort study
AU - Watanabe, Natsumi
AU - Sawada, Susumu S.
AU - Shimada, Kazunori
AU - Lee, I. Min
AU - Gando, Yuko
AU - Momma, Haruki
AU - Kawakami, Ryoko
AU - Miyachi, Motohiko
AU - Hagi, Yumiko
AU - Kinugawa, Chihiro
AU - Okamoto, Takashi
AU - Tsukamoto, Koji
AU - Blair, Steven N.
N1 - Funding Information:
This work was supported by the National Institutes of Biomedical Innovation, Health and Nutrition, and a collaborative research grant from the Juntendo University Graduate School of Health and Sports Science and the Institute of Health and Sports Science and Medicine (1521224, NW).
Funding Information:
The authors thank the study participants and the physicians and medical staff of Tokyo Gas Company for assisting with the data collection. This work was supported by the National Institutes of Biomedical Innovation, Health and Nutrition, and a collaborative research grant from the Juntendo University Graduate School of Health and Sports Science and the Institute of Health and Sports Science and Medicine (1521224, NW).
Publisher Copyright:
© 2018 Japan Atherosclerosis Society.
PY - 2018
Y1 - 2018
N2 - Aim: Recent studies have suggested that non-high-density lipoprotein cholesterol (non-HDL-C) may be a good marker of coronary heart disease and cardiovascular disease risk. Therefore, we investigated the relationship between cardiorespiratory fitness (CRF) and non-HDL-C.Methods: We evaluated CRF and the incidence of high level of non-HDL-C in 4,067 Japanese men without dyslipidemia. The participants were given a submaximal exercise test, a medical examination, and questionnaires on their health habits in 1986. A cycle ergometer was used to measure the CRF and maximal oxygen uptake was estimated. The incidence of a high level of non-HDL-C (≥170 mg/dL) from 1986 to 2006 was ascertained based on the fasting blood levels. A high level of non-HDL-C was found in 1,482 participants during the follow-up. Cox proportional hazard models were used to obtain the hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of a high level of non-HDL-C.Results: Following age adjustment, and using the lowest CRF group (quartileⅠ) as reference, the HRs and 95% CIs for quartiles Ⅱ through Ⅳ were: 1.00 (95% CI: 0.87 –1.15), 0.87 (95% CI: 0.76 –1.00), and 0.70 (95% CI: 0.60 – 0.81), respectively (P for trend＜0.001). After additional adjustment for body mass index, systolic blood pressure, smoking, alcohol intake, and family history of dyslipidemia, the HRs and 95% CIs were: 1.05 (95% CI: 0.92–1.21), 0.94 (95% CI: 0.81–1.08), and 0.79 (95% CI: 0.67–0.92), respectively (P for trend=0.001).Conclusions: These results suggest that there is an inverse relationship between CRF levels and the incidence of a high level of non-HDL-C in Japanese men.
AB - Aim: Recent studies have suggested that non-high-density lipoprotein cholesterol (non-HDL-C) may be a good marker of coronary heart disease and cardiovascular disease risk. Therefore, we investigated the relationship between cardiorespiratory fitness (CRF) and non-HDL-C.Methods: We evaluated CRF and the incidence of high level of non-HDL-C in 4,067 Japanese men without dyslipidemia. The participants were given a submaximal exercise test, a medical examination, and questionnaires on their health habits in 1986. A cycle ergometer was used to measure the CRF and maximal oxygen uptake was estimated. The incidence of a high level of non-HDL-C (≥170 mg/dL) from 1986 to 2006 was ascertained based on the fasting blood levels. A high level of non-HDL-C was found in 1,482 participants during the follow-up. Cox proportional hazard models were used to obtain the hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of a high level of non-HDL-C.Results: Following age adjustment, and using the lowest CRF group (quartileⅠ) as reference, the HRs and 95% CIs for quartiles Ⅱ through Ⅳ were: 1.00 (95% CI: 0.87 –1.15), 0.87 (95% CI: 0.76 –1.00), and 0.70 (95% CI: 0.60 – 0.81), respectively (P for trend＜0.001). After additional adjustment for body mass index, systolic blood pressure, smoking, alcohol intake, and family history of dyslipidemia, the HRs and 95% CIs were: 1.05 (95% CI: 0.92–1.21), 0.94 (95% CI: 0.81–1.08), and 0.79 (95% CI: 0.67–0.92), respectively (P for trend=0.001).Conclusions: These results suggest that there is an inverse relationship between CRF levels and the incidence of a high level of non-HDL-C in Japanese men.
KW - Cholesterol
KW - Cohort study
KW - Epidemiology
KW - Exercise test
KW - Non-high-density lipoprotein cholesterol
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U2 - 10.5551/jat.43851
DO - 10.5551/jat.43851
M3 - Article
C2 - 30089756
AN - SCOPUS:85058936071
VL - 25
SP - 1196
EP - 1205
JO - Journal of Atherosclerosis and Thrombosis
JF - Journal of Atherosclerosis and Thrombosis
SN - 1340-3478
IS - 12
ER -