TY - JOUR
T1 - Relationship between cardiorespiratory fitness and non-high-density lipoprotein cholesterol
T2 - A cohort study
AU - Watanabe, Natsumi
AU - Sawada, Susumu S.
AU - Shimada, Kazunori
AU - Lee, I. Min
AU - Gando, Yuko
AU - Momma, Haruki
AU - Kawakami, Ryoko
AU - Miyachi, Motohiko
AU - Hagi, Yumiko
AU - Kinugawa, Chihiro
AU - Okamoto, Takashi
AU - Tsukamoto, Koji
AU - Blair, Steven N.
N1 - Funding Information:
This work was supported by the National Institutes of Biomedical Innovation, Health and Nutrition, and a collaborative research grant from the Juntendo University Graduate School of Health and Sports Science and the Institute of Health and Sports Science and Medicine (1521224, NW).
PY - 2018
Y1 - 2018
N2 - Aim: Recent studies have suggested that non-high-density lipoprotein cholesterol (non-HDL-C) may be a good marker of coronary heart disease and cardiovascular disease risk. Therefore, we investigated the relationship between cardiorespiratory fitness (CRF) and non-HDL-C.Methods: We evaluated CRF and the incidence of high level of non-HDL-C in 4,067 Japanese men without dyslipidemia. The participants were given a submaximal exercise test, a medical examination, and questionnaires on their health habits in 1986. A cycle ergometer was used to measure the CRF and maximal oxygen uptake was estimated. The incidence of a high level of non-HDL-C (≥170 mg/dL) from 1986 to 2006 was ascertained based on the fasting blood levels. A high level of non-HDL-C was found in 1,482 participants during the follow-up. Cox proportional hazard models were used to obtain the hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of a high level of non-HDL-C.Results: Following age adjustment, and using the lowest CRF group (quartileⅠ) as reference, the HRs and 95% CIs for quartiles Ⅱ through Ⅳ were: 1.00 (95% CI: 0.87 –1.15), 0.87 (95% CI: 0.76 –1.00), and 0.70 (95% CI: 0.60 – 0.81), respectively (P for trend<0.001). After additional adjustment for body mass index, systolic blood pressure, smoking, alcohol intake, and family history of dyslipidemia, the HRs and 95% CIs were: 1.05 (95% CI: 0.92–1.21), 0.94 (95% CI: 0.81–1.08), and 0.79 (95% CI: 0.67–0.92), respectively (P for trend=0.001).Conclusions: These results suggest that there is an inverse relationship between CRF levels and the incidence of a high level of non-HDL-C in Japanese men.
AB - Aim: Recent studies have suggested that non-high-density lipoprotein cholesterol (non-HDL-C) may be a good marker of coronary heart disease and cardiovascular disease risk. Therefore, we investigated the relationship between cardiorespiratory fitness (CRF) and non-HDL-C.Methods: We evaluated CRF and the incidence of high level of non-HDL-C in 4,067 Japanese men without dyslipidemia. The participants were given a submaximal exercise test, a medical examination, and questionnaires on their health habits in 1986. A cycle ergometer was used to measure the CRF and maximal oxygen uptake was estimated. The incidence of a high level of non-HDL-C (≥170 mg/dL) from 1986 to 2006 was ascertained based on the fasting blood levels. A high level of non-HDL-C was found in 1,482 participants during the follow-up. Cox proportional hazard models were used to obtain the hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of a high level of non-HDL-C.Results: Following age adjustment, and using the lowest CRF group (quartileⅠ) as reference, the HRs and 95% CIs for quartiles Ⅱ through Ⅳ were: 1.00 (95% CI: 0.87 –1.15), 0.87 (95% CI: 0.76 –1.00), and 0.70 (95% CI: 0.60 – 0.81), respectively (P for trend<0.001). After additional adjustment for body mass index, systolic blood pressure, smoking, alcohol intake, and family history of dyslipidemia, the HRs and 95% CIs were: 1.05 (95% CI: 0.92–1.21), 0.94 (95% CI: 0.81–1.08), and 0.79 (95% CI: 0.67–0.92), respectively (P for trend=0.001).Conclusions: These results suggest that there is an inverse relationship between CRF levels and the incidence of a high level of non-HDL-C in Japanese men.
KW - Cholesterol
KW - Cohort study
KW - Epidemiology
KW - Exercise test
KW - Non-high-density lipoprotein cholesterol
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U2 - 10.5551/jat.43851
DO - 10.5551/jat.43851
M3 - Article
C2 - 30089756
AN - SCOPUS:85058936071
VL - 25
SP - 1196
EP - 1205
JO - Journal of Atherosclerosis and Thrombosis
JF - Journal of Atherosclerosis and Thrombosis
SN - 1340-3478
IS - 12
ER -