Relationship between cold tolerance and generation of suppressor macrophages during acute cold stress

Takako Kizaki, Tomomi Ookawara, Tetsuya Izawa, Junichi Nagasawa, Shukoh Haga, Zsolt Radak, Hideki Ohno

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Acute cold stress induces suppressor macrophages expressing large numbers of receptors to the crystallizable fragment (Fc) portion of immunoglobulin G (MAC-1+FcγRII/III(bright) cells), resulting in the immunosuppression of splenocyte mitogenesis. The generation of MAC- 1+FcγRII/III(bright) cells is mediated by the action of glucocorticoids (GCs) through the GC-receptor. In the present study, the generation of MAC- 1+FcγRII/III(bright) cells in peritoneal exudate cells was closely related to the decrease of rectal temperature during 3-day exposure to 5°C. We next investigated the effects of improved cold tolerance on the generation of MAC- 1+FcγRII/III(bright) cells during acute cold stress. Mice were adapted to cold by exposure to 5 °C for 3 wk (cold-acclimated mice) and then reexposed to 5°C for 3 h (acute cold stress) after living at 25°C for 24 h. The rectal temperature of cold-acclimated mice was not decreased by the acute cold stress. In addition, the proportion of MAC-1+FcγRII/III(bright) III(bright) cells in peritoneal exudate cell population from cold acclimated mice was unaffected by the acute cold stress. The cold acclimation significantly attenuated the increases in serum corticosterone levels and the expression of the GC receptor mRNA on peritoneal exudate cells in response to acute cold stress. These results suggest that the altered GC response to acute cold stress by the improvement of cold tolerance inhibits the generation of suppressor macrophages during acute cold stress.

Original languageEnglish
Pages (from-to)1116-1122
Number of pages7
JournalJournal of Applied Physiology
Volume83
Issue number4
Publication statusPublished - 1997 Oct 1
Externally publishedYes

Fingerprint

Macrophages
Exudates and Transudates
Glucocorticoid Receptors
Glucocorticoids
Immunoglobulin Fc Fragments
Acclimatization
Corticosterone
Immunosuppression
Immunoglobulin G
Messenger RNA
Temperature

Keywords

  • Brown adipose tissue
  • Cold acclimation
  • Cold stress
  • Glucocorticoid
  • Immunosuppression

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Kizaki, T., Ookawara, T., Izawa, T., Nagasawa, J., Haga, S., Radak, Z., & Ohno, H. (1997). Relationship between cold tolerance and generation of suppressor macrophages during acute cold stress. Journal of Applied Physiology, 83(4), 1116-1122.

Relationship between cold tolerance and generation of suppressor macrophages during acute cold stress. / Kizaki, Takako; Ookawara, Tomomi; Izawa, Tetsuya; Nagasawa, Junichi; Haga, Shukoh; Radak, Zsolt; Ohno, Hideki.

In: Journal of Applied Physiology, Vol. 83, No. 4, 01.10.1997, p. 1116-1122.

Research output: Contribution to journalArticle

Kizaki, T, Ookawara, T, Izawa, T, Nagasawa, J, Haga, S, Radak, Z & Ohno, H 1997, 'Relationship between cold tolerance and generation of suppressor macrophages during acute cold stress', Journal of Applied Physiology, vol. 83, no. 4, pp. 1116-1122.
Kizaki, Takako ; Ookawara, Tomomi ; Izawa, Tetsuya ; Nagasawa, Junichi ; Haga, Shukoh ; Radak, Zsolt ; Ohno, Hideki. / Relationship between cold tolerance and generation of suppressor macrophages during acute cold stress. In: Journal of Applied Physiology. 1997 ; Vol. 83, No. 4. pp. 1116-1122.
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