Relationship between flavonoid structure and reactive oxygen species generation upon ultraviolet and X-ray irradiation

Lei Jiang, Emiko Yanase, Takashi Mori, Kanae Kurata, Michiru Toyama, Ayaka Tsuchiya, Kosei Yamauchi, Tohru Mitsunaga, Hitoshi Iwahashi, Junko Takahashi

Research output: Contribution to journalArticlepeer-review

Abstract

In this research, we aimed to reveal structures related to reactive oxygen species (ROS) generation of flavonoids upon ultraviolet (UV) or X-ray irradiation. ROS production of selected flavonoids was studied by using ROS fluorescence probes. We discuss the relationship between the structures of the flavonoids and the generation of three ROSs, superoxide anion radical (O2 •−), hydroxyl radical (OH), and singlet oxygen (1O2). Results showed that 2,3-double bond was an key structure for natural flavonoids to generate O2 •−. We also discuss the effects of the ROS scavenging capacities on ROS generation through oxygen radical absorbance capacity (ORAC) tests. Derivatives of quercetin could produce OH due to differences of ROS scavenging ability. Our results indicated that flavonoids and their derivatives, which were used as antioxidant reagents, can serve as ROS generators upon ultraviolet (UV) or X-ray irradiation.

Original languageEnglish
Article number112044
JournalJournal of Photochemistry and Photobiology A: Chemistry
Volume384
DOIs
Publication statusPublished - 2019 Nov 1
Externally publishedYes

Keywords

  • Cancer radiotherapy
  • Free radicals
  • Non-ionizing and ionizing radiation
  • ORAC
  • Radiosensitizer

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Physics and Astronomy(all)

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