Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells

Masataka Uchida, Eri Oyanagi, Motohiko Miyachi, Akira Yamauchi, Hiromi Yano

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We investigated the effect of macrophage differentiation on the chemotactic activity to invade local damaged myoblasts using in vitro models of muscle injury. We found that: 1) the chemotactic activity of macrophages toward areas of damaged myoblasts might be induced more by live myoblasts than dead ones, 2) the chemotactic activity of macrophages is not due to velocity, but depends on the directionality toward damaged myoblast cells, and 3) macrophage differentiation strongly influence the chemotactic activity toward damaged myoblast cells through the expression of CCR2 and/or F-actin.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalJournal of Immunological Methods
Volume393
Issue number1-2
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • CCR2
  • Dexamethasone
  • F-actin
  • Lipopolysaccharide
  • TAXIScan

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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