Relationship between tartrate-resistant acid phosphatase 5b and stress fractures in female athletes

Sayaka Nose-Ogura, Osamu Yoshino, Michiko Dohi, Suguru Torii, Mika Kigawa, Miyuki Harada, Osamu Hiraike, Takashi Kawahara, Yutaka Osuga, Tomoyuki Fujii, Shigeru Saito

Research output: Contribution to journalArticle

Abstract

Background: Approximately 10% of female athletes have a history of stress fractures, which most commonly occur between the ages of 16 and 17 years old. Purpose: We investigated whether tartrate-resistant acid phosphatase 5b (TRACP-5b), which is a bone resorption marker, can serve as a valid predictor of stress fractures in female athletes in their teens and 20s. Methods: Three hundred and sixteen elite female athletes were recruited between 2013 and 2015. Serum TRACP-5b and various hormones were examined in blood samples. The serum TRACP-5b level was compared between athletes with and without stress fractures within 3 months after the initial collection of their blood samples. Results: The 316 athletes were divided into two age groups: 13–19 years old and 20–29 years old. Thirty-six athletes (11.4%) experienced new stress fractures within 3 months after the initial collection of their blood samples. The median serum TRACP-5b level was significantly higher in teenage athletes with new stress fractures than in teenage athletes without new stress fractures. In univariate logistic regression analysis, the Z-score of serum TRACP-5b was a significant predictive factor of stress fractures in teenage athletes only (odds ratio: 1.87; 95% CI: 1.31–2.66; P < 0.0012). Conclusion: For teenage female athletes, TRACP-5b is a predictor of the risk of stress fractures, and measuring TRACP-5b levels may be useful to prevent stress fractures.

Original languageEnglish
Pages (from-to)1436-1442
Number of pages7
JournalJournal of Obstetrics and Gynaecology Research
Volume46
Issue number8
DOIs
Publication statusPublished - 2020 Aug 1

Keywords

  • bone resorption marker
  • prevention
  • prospective study

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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    Nose-Ogura, S., Yoshino, O., Dohi, M., Torii, S., Kigawa, M., Harada, M., Hiraike, O., Kawahara, T., Osuga, Y., Fujii, T., & Saito, S. (2020). Relationship between tartrate-resistant acid phosphatase 5b and stress fractures in female athletes. Journal of Obstetrics and Gynaecology Research, 46(8), 1436-1442. https://doi.org/10.1111/jog.14256