Relationship between the grades of a learned aversive-feeding response and the dopamine contents in Lymnaea

Hitoshi Aonuma, Mugiho Kaneda, Dai Hatakeyama, Takayuki Watanabe, Ken Lukowiak, Etsuro Ito

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    The pond snail Lymnaea learns conditioned taste aversion (CTA) and remembers not to respond to food substances that initially cause a feeding response. The possible relationship between how well snails learn to follow taste-aversion training and brain dopamine contents is not known. We examined this relationship and found the following: first, snails in the act of eating just before the commencement of CTA training were poor learners and had the highest dopamine contents in the brain; second, snails which had an ad libitum access to food, but were not eating just before training, were average learners and had lower dopamine contents; third, snails food-deprived for one day before training were the best learners and had significantly lower contents of dopamine compared to the previous two cohorts. There was a negative correlation between the CTA grades and the brain dopamine contents in these three cohorts. Fourth, snails fooddeprived for five days before training were poor learners and had higher dopamine contents. Thus, severe hunger increased the dopamine content in the brain. Because dopamine functions as a reward transmitter, CTA in the severely deprived snails (i.e. the fourth cohort) was thought to be mitigated by a high dopamine content.

    Original languageEnglish
    Pages (from-to)1869-1873
    Number of pages5
    JournalBiology Open
    Volume5
    Issue number12
    DOIs
    Publication statusPublished - 2016 Dec 15

    Fingerprint

    Lymnaea
    dopamine
    Snails
    Dopamine
    snails
    Brain
    brain
    Food
    Eating
    ingestion
    Hunger
    Ponds
    hunger
    Reward
    Transmitters

    Keywords

    • Conditioned taste aversion
    • Dopamine
    • Food deprivation
    • Long-term memory
    • Lymnaea

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)

    Cite this

    Relationship between the grades of a learned aversive-feeding response and the dopamine contents in Lymnaea. / Aonuma, Hitoshi; Kaneda, Mugiho; Hatakeyama, Dai; Watanabe, Takayuki; Lukowiak, Ken; Ito, Etsuro.

    In: Biology Open, Vol. 5, No. 12, 15.12.2016, p. 1869-1873.

    Research output: Contribution to journalArticle

    Aonuma, Hitoshi ; Kaneda, Mugiho ; Hatakeyama, Dai ; Watanabe, Takayuki ; Lukowiak, Ken ; Ito, Etsuro. / Relationship between the grades of a learned aversive-feeding response and the dopamine contents in Lymnaea. In: Biology Open. 2016 ; Vol. 5, No. 12. pp. 1869-1873.
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