Relationship between trait anxiety, brain activity and natural killer cell activity in cancer patients: A preliminary pet study

Manabu Tashiro, Masatoshi Itoh, Kazuo Kubota, Hiroaki Kumano, Mehedi M. Masud, Ernst Moser, Hiroyuki Arai, Hidetada Sasaki

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The purpose of this study is to examine the relationship between psychological factors, regional brain activity and natural killer cell activity (NKA). Eight patients with malignant diseases were studied by FDG-PET under a resting condition. NKA and degree of anxiety and depression were measured using Taylor's manifest anxiety scale (MAS) and Zung's self-rating depression scale (SDS). Linear correlation of NKA and psychological measures to the regional brain metabolism in cancer patients was examined using statistical parametric mapping (SPM). Positive linear correlation between NKA and regional metabolic rate ratios was identified in the visual association cortex, anterior cingulate gyrus (CG) and sensorimotor area, and negative correlation was identified in the inferolateral prefrontal cortex (ILPFC), prefrontal cortex (PFC), orbitofrontal cortex (OFC) and anterior temporal cortex. Positive linear correlation to the MAS score was identified in the visual association cortex, anterior CG, primary sensorimotor area and the posterior parietal cortex, and negative correlation was detected in the ILPFC, PFC, OFC and anterior temporal cortex. The NKA and MAS scores positively correlated with each other (p<0.001). The result might serve as supporting data for a hypothesis that psycho-immune interaction is also mediated by the cerebral cortex and limbic system.

Original languageEnglish
Pages (from-to)541-546
Number of pages6
JournalPsycho-Oncology
Volume10
Issue number6
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Pets
Prefrontal Cortex
Natural Killer Cells
brain
cancer
Anxiety
Manifest Anxiety Scale
anxiety
Gyrus Cinguli
Brain
Neoplasms
Visual Cortex
Temporal Lobe
Depression
Psychology
Limbic System
Parietal Lobe
psychological factors
Cerebral Cortex
rating

ASJC Scopus subject areas

  • Oncology
  • Psychology(all)
  • Social Sciences (miscellaneous)

Cite this

Relationship between trait anxiety, brain activity and natural killer cell activity in cancer patients : A preliminary pet study. / Tashiro, Manabu; Itoh, Masatoshi; Kubota, Kazuo; Kumano, Hiroaki; Masud, Mehedi M.; Moser, Ernst; Arai, Hiroyuki; Sasaki, Hidetada.

In: Psycho-Oncology, Vol. 10, No. 6, 2001, p. 541-546.

Research output: Contribution to journalArticle

Tashiro, Manabu ; Itoh, Masatoshi ; Kubota, Kazuo ; Kumano, Hiroaki ; Masud, Mehedi M. ; Moser, Ernst ; Arai, Hiroyuki ; Sasaki, Hidetada. / Relationship between trait anxiety, brain activity and natural killer cell activity in cancer patients : A preliminary pet study. In: Psycho-Oncology. 2001 ; Vol. 10, No. 6. pp. 541-546.
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