Relative blood damage index of the jellyfish valve and the Bjork-Shiley tilting-disk valve

Yos Morsi, Masahisa Kogure, Mitsuo Umezu

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Determination of the potential for blood cell damage induced by artificial heart valves is essential in deciding the suitability of the valve for clinical use. Both the magnitude and the duration of the shear stress influence the onset and severity of the damage to the constituents of blood. In this study, in vitro shear stress measurements of the mitral jellyfish and Bjork-Shiley tilting-disk (mono) prosthetic valves under physiological pulsatile flow conditions were conducted. The data indicate that elevated levels of shear stress occurred mainly ID downstream from both valves. With the aid of a mathematical model and using the elevated shear stress data, the relative release of hemoglobin by damaged red blood cells and of lactate dehydrogenase by platelets was computed for both valves. For the operating conditions examined, the jellyfish valve was found to cause the least damage to blood, with a relative blood damage index of 0.27 against a value of 0.47 for the Bjork-Shiley valve.

    Original languageEnglish
    Pages (from-to)163-169
    Number of pages7
    JournalJournal of Artificial Organs
    Volume2
    Issue number2
    Publication statusPublished - 1999

    Fingerprint

    Blood
    Shear stress
    Artificial Heart
    Pulsatile Flow
    Heart Valves
    L-Lactate Dehydrogenase
    Cells
    Blood Cells
    Artificial heart
    Hemoglobins
    Theoretical Models
    Blood Platelets
    Pulsatile flow
    Erythrocytes
    Hemoglobin
    Stress measurement
    Platelets
    Prosthetics
    Mathematical models
    In Vitro Techniques

    Keywords

    • Artificial heart valves
    • LDA measurements
    • Relative blood damage index

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Relative blood damage index of the jellyfish valve and the Bjork-Shiley tilting-disk valve. / Morsi, Yos; Kogure, Masahisa; Umezu, Mitsuo.

    In: Journal of Artificial Organs, Vol. 2, No. 2, 1999, p. 163-169.

    Research output: Contribution to journalArticle

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