REM sleep, prefrontal theta, and the consolidation of human emotional memory

Masaki Nishida, Jori Pearsall, Randy L. Buckner, Matthew P. Walker

Research output: Contribution to journalArticle

309 Citations (Scopus)

Abstract

Both emotion and sleep are independently known to modulate declarative memory. Memory can be facilitated by emotion, leading to enhanced consolidation across increasing time delays. Sleep also facilitates offline memory processing, resulting in superior recall the next day. Here we explore whether rapid eye movement (REM) sleep, and aspects of its unique neurophysiology, underlie these convergent influences on memory. Using a nap paradigm, we measured the consolidation of neutral and negative emotional memories, and the association with REM-sleep electrophysiology. Subjects that napped showed a consolidation benefit for emotional but not neutral memories. The No-Nap control group showed no evidence of a consolidation benefit for either memory type. Within the Nap group, the extent of emotional memory facilitation was significantly correlated with the amount of REM sleep and also with right-dominant prefrontal theta power during REM. Together, these data support the role of REM-sleep neurobiology in the consolidation of emotional human memories, findings that have direct translational implications for affective psychiatric and mood disorders.

Original languageEnglish
Pages (from-to)1158-1166
Number of pages9
JournalCerebral Cortex
Volume19
Issue number5
DOIs
Publication statusPublished - 2009 May
Externally publishedYes

Fingerprint

REM Sleep
Sleep
Mood Disorders
Emotions
Neurophysiology
Neurobiology
Electrophysiology
Psychiatry
Control Groups

Keywords

  • Consolidation
  • Emotion
  • Memory
  • Prefrontal
  • REM
  • Theta

ASJC Scopus subject areas

  • Medicine(all)
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience

Cite this

REM sleep, prefrontal theta, and the consolidation of human emotional memory. / Nishida, Masaki; Pearsall, Jori; Buckner, Randy L.; Walker, Matthew P.

In: Cerebral Cortex, Vol. 19, No. 5, 05.2009, p. 1158-1166.

Research output: Contribution to journalArticle

Nishida, Masaki ; Pearsall, Jori ; Buckner, Randy L. ; Walker, Matthew P. / REM sleep, prefrontal theta, and the consolidation of human emotional memory. In: Cerebral Cortex. 2009 ; Vol. 19, No. 5. pp. 1158-1166.
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