Reoxygenation in tumor tissues after X-ray or carbon-12 irradiation

Takeshi Fukawa, Koji Takematsu, Kotaro Oka, Nobuyuki Miyahara, Sachiko Koike, Koichi Ando, Hirosuke Kobayashi, Kazuo Tanishita

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We measured directly the partial pressure of oxygen (pO 2) in new fibrosarcoma (NFSa) tumors grown in C3H/He mice using microcoaxial O 2 electrodes in vivo. The pO 2 in tumors was monitored after a single dose of X-ray or carbon-12 irradiation. After irradiation, tumor volume temporally shrinked, and pO 2 simultaneously increased. Carbon-12 irradiation reoxygenated tumors between the 1st and 9th day after the irradiation, while x-ray irradiation reoxygenated tumors between the 3rd and 8th day. We found that reoxygenation period after carbon-12 irradiation started earlier and continued longer than X-ray irradiation.

Original languageEnglish
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Pages371-372
Number of pages2
Volume39
Publication statusPublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Fukawa, T., Takematsu, K., Oka, K., Miyahara, N., Koike, S., Ando, K., Kobayashi, H., & Tanishita, K. (1998). Reoxygenation in tumor tissues after X-ray or carbon-12 irradiation. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 39, pp. 371-372)