Reproductive neuroendocrinology of mammalian gonadotropin-inhibitory hormone

Takayoshi Ubuka, Kazuyoshi Tsutsui

Research output: Contribution to journalReview article

Abstract

Background: Gonadotropin-inhibitory hormone (GnIH) was discovered in the Japanese quail brain in 2000 as a hypothalamic neuropeptide that suppresses luteinizing hormone release from cultured quail anterior pituitary. Methods: The authors investigated the existence of mammalian orthologous peptides to GnIH and their physiological functions in the following 19 years of research. Main findings: Mammals have orthologous peptide to GnIH, often described RFamide-related peptide, expressed in the hypothalamus and gonads. Mammalian GnIH may also suppress gonadotropin synthesis and release by suppressing gonadotropin-releasing hormone (GnRH) synthesis and release in addition to directly suppressing gonadotropin synthesis and release from the pituitary. Mammalian GnIH may also suppress kisspeptin, a stimulator of GnRH, release. Mammalian GnIH is also expressed in the testis and ovary and suppresses gametogenesis and sex steroid production acting in an autocrine/paracrine manner. Thus, mammalian GnIH may act at all levels of the hypothalamic-pituitary-gonadal axis to suppress reproduction. GnIH may be involved in the regulation of puberty, estrous or menstrual cycle, seasonal reproduction, and stress responses. Conclusion: Studies suggest that mammalian GnIH is an important neuroendocrine suppressor of reproduction in mammals.

Original languageEnglish
Pages (from-to)225-233
Number of pages9
JournalReproductive Medicine and Biology
Volume18
Issue number3
DOIs
Publication statusPublished - 2019 Jul 1

Fingerprint

Neuroendocrinology
Gonadotropins
Hormones
Reproduction
Gonadotropin-Releasing Hormone
Mammals
Kisspeptins
Gametogenesis
Coturnix
Peptides
Quail
Estrous Cycle
Gonads
Puberty
Menstrual Cycle
Luteinizing Hormone
Neuropeptides
Hypothalamus
Testis
Ovary

Keywords

  • gonadotropin-inhibitory hormone
  • gonadotropin-releasing hormone
  • kisspeptin
  • reproduction
  • RFamide-related peptide

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

Cite this

Reproductive neuroendocrinology of mammalian gonadotropin-inhibitory hormone. / Ubuka, Takayoshi; Tsutsui, Kazuyoshi.

In: Reproductive Medicine and Biology, Vol. 18, No. 3, 01.07.2019, p. 225-233.

Research output: Contribution to journalReview article

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