Research and development of magnetic drug delivery system using bulk high temperature superconducting magnet

Shigehiro Nishijima, Fumihito Mishima, Yasuhiko Tabata, Hiroshi Iseki, Yoshihiro Muragaki, Akira Sasaki, Norihide Saho

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The magnetic force control of the drug motion in the body has been studied in the current work. The calculation was made to study the possibility of the magnetic force control of the drag motion from outside of the body. The condition which enables the magnetic force control was clarified. The magnetic drug delivery system (MDDS) was demonstrated to be possible using the rat and permanent magnet and the validity of the calculation was confirmed by experiment. The magnetite suspension was introduced into a liver through portal vein in the rat experiment. A permanent magnet was used to navigate the magnetite. The navigation and accumulation of the magnetite was successfully performed. Based on the results, the MDDS experiment was made with an HTS magnet for a large-sized animal, pig. The HTS magnet of which size was 45 mm in diameter and 90 mm in length produced 5 T at 38 K. The suspension of the magnetite was injected into the blood vessel of the pig. It was confirmed that the magnetite was successfully navigated and/or accumulated by the HTS magnet.

Original languageEnglish
Article number5109597
Pages (from-to)2257-2260
Number of pages4
JournalIEEE Transactions on Applied Superconductivity
Volume19
Issue number3
DOIs
Publication statusPublished - 2009 Jun
Externally publishedYes

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Keywords

  • Accumulation of magnetic seeded drug
  • Animal experiment
  • Bulk HTS magnet
  • Magnetic drug delivery system

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

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