Research on the pig liver esterase (PLE)-catalyzed kinetic resolution of half-esters derived from prochiral diesters

Naoyoshi Noguchi, Kazuhiro Tsuna, Masahisa Nakada

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    The pig liver esterase (PLE)-catalyzed kinetic resolution of half-esters derived from prochiral diesters is described. Generally, the PLE-catalyzed enantioselective hydrolysis of prochiral diesters affords the corresponding half-esters in high yield, because further hydrolysis of the half-esters does not typically occur. However, we found that some half-esters undergo PLE-catalyzed hydrolysis when they are gradually added to a PLE suspension in a potassium phosphate buffer at pH 8.0 via a syringe pump, leading to the kinetic resolution of the half-esters.

    Original languageEnglish
    Pages (from-to)357-361
    Number of pages5
    JournalTetrahedron Asymmetry
    Volume24
    Issue number7
    DOIs
    Publication statusPublished - 2013 Apr 15

    Fingerprint

    swine
    Esterases
    liver
    Liver
    esters
    Esters
    Kinetics
    kinetics
    hydrolysis
    Hydrolysis
    syringes
    Syringes
    potassium phosphates
    Potassium
    Suspensions
    Buffers
    Phosphates
    buffers
    Pumps
    pumps

    ASJC Scopus subject areas

    • Organic Chemistry
    • Inorganic Chemistry
    • Physical and Theoretical Chemistry
    • Catalysis

    Cite this

    Research on the pig liver esterase (PLE)-catalyzed kinetic resolution of half-esters derived from prochiral diesters. / Noguchi, Naoyoshi; Tsuna, Kazuhiro; Nakada, Masahisa.

    In: Tetrahedron Asymmetry, Vol. 24, No. 7, 15.04.2013, p. 357-361.

    Research output: Contribution to journalArticle

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