Resistance exercise training-induced muscle hypertrophy was associated with reduction of inflammatory markers in elderly women

Kishiko Ogawa, Kiyoshi Sanada, Shuichi MacHida, Mitsuharu Okutsu, Katsuhiko Suzuki

Research output: Contribution to journalArticle

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Abstract

Aging is associated with low-grade inflammation. The benefits of regular exercise for the elderly are well established, whereas less is known about the impact of low-intensity resistance exercise on low-grade inflammation in the elderly. Twenty-one elderly women (mean age ± SD, 85.0 ± 4.5 years) participated in 12 weeks of resistance exercise training. Muscle thickness and circulating levels of C-reactive protein (CRP), serum amyloid A (SAA), heat shock protein (HSP)70, tumor necrosis factor (TNF)-, interleukin (IL)-1, IL-6, monocyte chemotactic protein (MCP-1), insulin, insulin-like growth factor (IGF)-I, and vascular endothelial growth factor (VEGF) were measured before and after the exercise training. Training reduced the circulating levels of CRP, SAA (P<.05), HSP70, IGF-I, and insulin (P<.01). The training-induced reductions in CRP and TNF- were significantly (P<.01, P<.05) associated with increased muscle thickness (r=-0.61, r=-0.54), respectively. None of the results were significant after applying a Bonferroni correction. Resistance training may assist in maintaining or improving muscle volume and reducing low-grade inflammation.

Original languageEnglish
Article number171023
JournalMediators of Inflammation
Volume2010
DOIs
Publication statusPublished - 2010

Fingerprint

Resistance Training
Hypertrophy
C-Reactive Protein
Exercise
Serum Amyloid A Protein
Muscles
Inflammation
Insulin-Like Growth Factor I
Tumor Necrosis Factor-alpha
Insulin
HSP70 Heat-Shock Proteins
Chemokine CCL2
Interleukin-1
Vascular Endothelial Growth Factor A
Interleukin-6

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Resistance exercise training-induced muscle hypertrophy was associated with reduction of inflammatory markers in elderly women. / Ogawa, Kishiko; Sanada, Kiyoshi; MacHida, Shuichi; Okutsu, Mitsuharu; Suzuki, Katsuhiko.

In: Mediators of Inflammation, Vol. 2010, 171023, 2010.

Research output: Contribution to journalArticle

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