Resistance training-induced decreases in central arterial compliance is associated with increases in serum thromboxane B2 concentrations in young men

Kaname Tagawa, Song Gyu Ra, Hiroshi Kumagai, Yuriko Sawano, Kosaku Yamamoto, Toru Yoshikawa, Youngju Choi, Yasuko Yoshida, Kazuhiro Takekoshi, Seiji Maeda

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background: Reduction in central arterial compliance is an independent risk factor for cardiovascular disease, and is caused by high-intensity resistance training. The thromboxane has both potent vasoconstrictive and platelet aggregation effects, and is associated with cardiovascular diseases. However, whether thromboxane is involved in resistance training-induced decrease in central arterial compliance is unclear. The present study aimed to investigate relationships between circulating thromboxane levels and central arterial compliance in both cross-sectional and longitudinal (i.e., resistance training) designs. Methods and results: First, in a cross-sectional study, we assessed association between circulating thromboxane concentrations and central arterial compliance in 63 young men, who showed significant negative correlation between those parameters. Second, in a longitudinal study, we examined effects of high-intensity resistance training on circulating thromboxane concentrations and central arterial compliance and relationship among changes from baseline in those parameters. Young sedentary men were assigned to control (n = 7) or training (n = 17) groups. Subjects in training group underwent four-week supervised high-intensity resistance training. Resistance training significantly elevated circulating thromboxane concentrations and decreased central arterial compliance; no significant change was observed in control group, and there was significant correlation between changes in those parameters. Conclusions: circulating thromboxane is possible mechanism explaining resistance training-induced decrease in central arterial compliance in young men.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalArtery Research
Volume23
DOIs
Publication statusPublished - 2018 Sep
Externally publishedYes

Keywords

  • Carotid arterial compliance
  • Platelet aggregation
  • Resistance training
  • Vasoconstrictive mediator
  • Young men

ASJC Scopus subject areas

  • Anatomy
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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