Respiratory flow in a realistic tracheostenosis model

Toshihiro Sera, Sunao Satoh, Hirohisa Horinouchi, Koichi Kobayashi, Kazuo Tanishita

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The possible mechanism of wheeze generation in tracheostenosis was identified by measuring inspiratory and expiratory flow in a "morphological and distensible" realistic tracheostenosis model. The shape of the model was based on CT (Computed Tomography) images of a patient that had tracheostenosis. A trachea consists of tracheal cartilage rings and smooth muscle. Spatial variation of wall distensibility was achieved in the model by varying the wall thickness based on the elastic modulus measured in pig air-ways. The spatial variation influenced the flow in the airway and the turbulence production rate decreased faster at smooth muscles. Using the model, we investigated the mechanism of wheeze generation by focusing on the turbulence intensity. The turbulence intensity in expiratory flow was about twice that in inspiratory flow, and larger vortices existed in post-stenosis in expiratory flow, and thus might contribute to wheeze generation.

Original languageEnglish
Pages (from-to)461-471
Number of pages11
JournalJournal of Biomechanical Engineering
Volume125
Issue number4
DOIs
Publication statusPublished - 2003 Aug
Externally publishedYes

Fingerprint

Smooth Muscle
Turbulence
Elastic Modulus
Trachea
Cartilage
Muscle
Pathologic Constriction
Swine
Air
Tomography
Vortex flow
Elastic moduli

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics

Cite this

Sera, T., Satoh, S., Horinouchi, H., Kobayashi, K., & Tanishita, K. (2003). Respiratory flow in a realistic tracheostenosis model. Journal of Biomechanical Engineering, 125(4), 461-471. https://doi.org/10.1115/1.1589775

Respiratory flow in a realistic tracheostenosis model. / Sera, Toshihiro; Satoh, Sunao; Horinouchi, Hirohisa; Kobayashi, Koichi; Tanishita, Kazuo.

In: Journal of Biomechanical Engineering, Vol. 125, No. 4, 08.2003, p. 461-471.

Research output: Contribution to journalArticle

Sera, T, Satoh, S, Horinouchi, H, Kobayashi, K & Tanishita, K 2003, 'Respiratory flow in a realistic tracheostenosis model', Journal of Biomechanical Engineering, vol. 125, no. 4, pp. 461-471. https://doi.org/10.1115/1.1589775
Sera T, Satoh S, Horinouchi H, Kobayashi K, Tanishita K. Respiratory flow in a realistic tracheostenosis model. Journal of Biomechanical Engineering. 2003 Aug;125(4):461-471. https://doi.org/10.1115/1.1589775
Sera, Toshihiro ; Satoh, Sunao ; Horinouchi, Hirohisa ; Kobayashi, Koichi ; Tanishita, Kazuo. / Respiratory flow in a realistic tracheostenosis model. In: Journal of Biomechanical Engineering. 2003 ; Vol. 125, No. 4. pp. 461-471.
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