Restricted-feeding-induced anticipatory activity rhythm is associated with a phase-shift of the expression of mPer1 and mPer2 mRNA in the cerebral cortex and hippocampus but not in the suprachiasmatic nucleus of mice

Hisanori Wakamatsu, Yuko Yoshinobu, Reiko Aida, Takahiro Moriya, Masashi Akiyama, Shigenobu Shibata

    Research output: Contribution to journalArticle

    241 Citations (Scopus)

    Abstract

    Daily restricted feeding (RF) can produce food-entrainable oscillations in both intact and suprachiasmatic nucleus (SCN)-lesioned animals. Thus, there are two circadian rhythms, one of which is SCN-dependent and the other SCN-independent. Recently, it has been established that several mouse clock genes, such as mPer1, mPer2 and mPer3 are expressed in the SCN and other brain tissues. Although the role of mPer genes expressed in the SCN has recently been evaluated in the SCN-dependent rhythm, their function in the SCN-independent rhythm is still poorly understood. In order to understand the role of these genes in SCN-independent rhythm, we examined the expression pattern of mPer1 and mPer2 mRNA in each brain area of mice under RF. Mice were allowed access to food for 4 h during either the daytime under a light-dark cycle or the subjective daytime under constant dark. After 6 days of scheduled RF, the night-time or subjective night-time peak of mPer mRNA changed to a daytime peak in the cerebral cortex and hippocampus, with moderate expression in the striatum, pyriform cortex and paraventricular nucleus, and no expression in the SCN. The daytime peak in the cerebral cortex returned to a night-time peak after the release of RF to a free-feeding schedule. Although the basal rhythm of mPer expression disappeared in SCN-lesioned mice, RF produced mPer mRNA rhythm in the cerebral cortex of these mice. The present results provide evidence of an association between food-entrainable oscillations and the expression of mPer1 and mPer2 in the cerebral cortex and hippocampus.

    Original languageEnglish
    Pages (from-to)1190-1196
    Number of pages7
    JournalEuropean Journal of Neuroscience
    Volume13
    Issue number6
    DOIs
    Publication statusPublished - 2001

    Fingerprint

    Suprachiasmatic Nucleus
    Cerebral Cortex
    Hippocampus
    Messenger RNA
    Food
    Genes
    Paraventricular Hypothalamic Nucleus
    Photoperiod
    Brain
    Circadian Rhythm
    Appointments and Schedules

    Keywords

    • Cerebral cortex
    • Circadian rhythm
    • Food anticipatory activity
    • Hippocampus
    • mPer1
    • mPer2
    • Restricted feeding
    • Suprachiasmatic nucleus

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Restricted-feeding-induced anticipatory activity rhythm is associated with a phase-shift of the expression of mPer1 and mPer2 mRNA in the cerebral cortex and hippocampus but not in the suprachiasmatic nucleus of mice. / Wakamatsu, Hisanori; Yoshinobu, Yuko; Aida, Reiko; Moriya, Takahiro; Akiyama, Masashi; Shibata, Shigenobu.

    In: European Journal of Neuroscience, Vol. 13, No. 6, 2001, p. 1190-1196.

    Research output: Contribution to journalArticle

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    abstract = "Daily restricted feeding (RF) can produce food-entrainable oscillations in both intact and suprachiasmatic nucleus (SCN)-lesioned animals. Thus, there are two circadian rhythms, one of which is SCN-dependent and the other SCN-independent. Recently, it has been established that several mouse clock genes, such as mPer1, mPer2 and mPer3 are expressed in the SCN and other brain tissues. Although the role of mPer genes expressed in the SCN has recently been evaluated in the SCN-dependent rhythm, their function in the SCN-independent rhythm is still poorly understood. In order to understand the role of these genes in SCN-independent rhythm, we examined the expression pattern of mPer1 and mPer2 mRNA in each brain area of mice under RF. Mice were allowed access to food for 4 h during either the daytime under a light-dark cycle or the subjective daytime under constant dark. After 6 days of scheduled RF, the night-time or subjective night-time peak of mPer mRNA changed to a daytime peak in the cerebral cortex and hippocampus, with moderate expression in the striatum, pyriform cortex and paraventricular nucleus, and no expression in the SCN. The daytime peak in the cerebral cortex returned to a night-time peak after the release of RF to a free-feeding schedule. Although the basal rhythm of mPer expression disappeared in SCN-lesioned mice, RF produced mPer mRNA rhythm in the cerebral cortex of these mice. The present results provide evidence of an association between food-entrainable oscillations and the expression of mPer1 and mPer2 in the cerebral cortex and hippocampus.",
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    AU - Wakamatsu, Hisanori

    AU - Yoshinobu, Yuko

    AU - Aida, Reiko

    AU - Moriya, Takahiro

    AU - Akiyama, Masashi

    AU - Shibata, Shigenobu

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