Rhodamine-based fluorogenic probe for imaging biological thiol

Aya Shibata, Kazuhiro Furukawa, Hiroshi Abe, Satoshi Tsuneda, Yoshihiro Ito

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    84 Citations (Scopus)

    Abstract

    We have developed a new fluorescent probe for biological thiol. The probe was synthesized by the modification of the 2,4-dinitrobenzenesulfonyl group with rhodamine 110. The selective detection of thiol species such as cysteine or glutathione was achieved in biological conditions. Moreover, the probe was successfully applied to the imaging of thiol species in living human cells.

    Original languageEnglish
    Pages (from-to)2246-2249
    Number of pages4
    JournalBioorganic and Medicinal Chemistry Letters
    Volume18
    Issue number7
    DOIs
    Publication statusPublished - 2008 Apr 1

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    Keywords

    • Fluorescence
    • Imaging
    • Probe
    • Synthesis
    • Thiol

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Organic Chemistry
    • Drug Discovery
    • Pharmaceutical Science

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