Rhodium-catalyzed enantioselective [2+2+2] cycloaddition of diynes with unfunctionalized alkenes

Takanori Shibata, Ai Kawachi, Mika Ogawa, Yusuke Kuwata, Kyoji Tsuchikama, Kohei Endo

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A chiral rhodium complex catalyzed an enantioselective [2+2+2] cycloaddition of unsymmetrical diynes with norbornene, and tetracyclic products were obtained in good to excellent ee. The cycloaddition of a symmetrical diyne with styrene derivatives as coupling partners gave bicyclic products in good ee.

Original languageEnglish
Pages (from-to)12853-12859
Number of pages7
JournalTetrahedron
Volume63
Issue number52
DOIs
Publication statusPublished - 2007 Dec 24

Keywords

  • Cycloaddition
  • Enantioselective
  • Norbornene
  • Rhodium
  • Styrene

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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