Ring-Opening Fluorination of Isoxazoles

Masaaki Komatsuda, Hugo Ohki, Hiroki Kondo, Ayane Suto, Junichiro Yamaguchi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A ring-opening fluorination of isoxazoles has been developed. Upon treatment of isoxazoles with an electrophilic fluorinating agent (Selectfluor), fluorination followed by deprotonation leads to tertiary fluorinated carbonyl compounds. This method features mild reaction conditions, good functional group tolerance, and a simple experimental procedure. Diverse transformations of the resulting α-fluorocyanoketones were also demonstrated, furnishing a variety of fluorinated compounds.

Original languageEnglish
Pages (from-to)3270-3274
Number of pages5
JournalOrganic Letters
Volume24
Issue number17
DOIs
Publication statusPublished - 2022 May 6

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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