Risk factors for infection in patients with systemic lupus erythematosus

Takamichi Yuhara, Hiromiki Natsuda, Hiroyuki Takemura, Takao Akama, Hiroshi Suzuki, Kazuhide Yamane, Heihachiro Kashiwagi

Research output: Contribution to journalArticle

Abstract

Risk factors for infection were evaluated in patients with active SLE. The active SLE patients complicated by infection within one year after initiation of steroid therapy for SLE (n=19) were compared with those not complicated by infection (n=71) with regard to age, disease duration, laboratory findings, disease activity (SLE Disease Activity Index), and treatment. There was a significant difference in levels of serum albumin, urine protein, serum creatinine, blood urea nitrogen, serum IgA, IgG, and prednisolone dose between the two groups. By using logistic regression analysis, the dependence of infection on the above variables was investigated. The incidence of infection was significantly related to serum albumin level, the severity of SLE (the Healht and Welfare Ministry criteria) and initial prednisolone dose. The severity of SLE, urine protein level, pleural or pericardial effusion, age, and CH 50 were found to contribute in the decreasing order to serum albumin level. We conclude that hypoalbuminemia not only from proteinuria but also from other causes, such as the severity of SLE, may increase the risk of infection in patients with active SLE.

Original languageEnglish
Pages (from-to)431-439
Number of pages9
JournalJapanese Journal of Clinical Immunology
Volume15
Issue number5
DOIs
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Systemic Lupus Erythematosus
Infection
Serum Albumin
Prednisolone
Complement Hemolytic Activity Assay
Urine
Hypoalbuminemia
Pericardial Effusion
Blood Urea Nitrogen
Pleural Effusion
Proteinuria
Immunoglobulin A
Blood Proteins
Creatinine
Immunoglobulin G
Logistic Models
Steroids
Regression Analysis
Incidence
Therapeutics

Keywords

  • hypoalbimiinemia
  • infection
  • risk factor
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Yuhara, T., Natsuda, H., Takemura, H., Akama, T., Suzuki, H., Yamane, K., & Kashiwagi, H. (1992). Risk factors for infection in patients with systemic lupus erythematosus. Japanese Journal of Clinical Immunology, 15(5), 431-439. https://doi.org/10.2177/jsci.15.431

Risk factors for infection in patients with systemic lupus erythematosus. / Yuhara, Takamichi; Natsuda, Hiromiki; Takemura, Hiroyuki; Akama, Takao; Suzuki, Hiroshi; Yamane, Kazuhide; Kashiwagi, Heihachiro.

In: Japanese Journal of Clinical Immunology, Vol. 15, No. 5, 1992, p. 431-439.

Research output: Contribution to journalArticle

Yuhara, T, Natsuda, H, Takemura, H, Akama, T, Suzuki, H, Yamane, K & Kashiwagi, H 1992, 'Risk factors for infection in patients with systemic lupus erythematosus', Japanese Journal of Clinical Immunology, vol. 15, no. 5, pp. 431-439. https://doi.org/10.2177/jsci.15.431
Yuhara, Takamichi ; Natsuda, Hiromiki ; Takemura, Hiroyuki ; Akama, Takao ; Suzuki, Hiroshi ; Yamane, Kazuhide ; Kashiwagi, Heihachiro. / Risk factors for infection in patients with systemic lupus erythematosus. In: Japanese Journal of Clinical Immunology. 1992 ; Vol. 15, No. 5. pp. 431-439.
@article{66d157818a724a0098658b3895228370,
title = "Risk factors for infection in patients with systemic lupus erythematosus",
abstract = "Risk factors for infection were evaluated in patients with active SLE. The active SLE patients complicated by infection within one year after initiation of steroid therapy for SLE (n=19) were compared with those not complicated by infection (n=71) with regard to age, disease duration, laboratory findings, disease activity (SLE Disease Activity Index), and treatment. There was a significant difference in levels of serum albumin, urine protein, serum creatinine, blood urea nitrogen, serum IgA, IgG, and prednisolone dose between the two groups. By using logistic regression analysis, the dependence of infection on the above variables was investigated. The incidence of infection was significantly related to serum albumin level, the severity of SLE (the Healht and Welfare Ministry criteria) and initial prednisolone dose. The severity of SLE, urine protein level, pleural or pericardial effusion, age, and CH 50 were found to contribute in the decreasing order to serum albumin level. We conclude that hypoalbuminemia not only from proteinuria but also from other causes, such as the severity of SLE, may increase the risk of infection in patients with active SLE.",
keywords = "hypoalbimiinemia, infection, risk factor, systemic lupus erythematosus",
author = "Takamichi Yuhara and Hiromiki Natsuda and Hiroyuki Takemura and Takao Akama and Hiroshi Suzuki and Kazuhide Yamane and Heihachiro Kashiwagi",
year = "1992",
doi = "10.2177/jsci.15.431",
language = "English",
volume = "15",
pages = "431--439",
journal = "Immunological Medicine",
issn = "0911-4300",
publisher = "Taylor and Francis Ltd.",
number = "5",

}

TY - JOUR

T1 - Risk factors for infection in patients with systemic lupus erythematosus

AU - Yuhara, Takamichi

AU - Natsuda, Hiromiki

AU - Takemura, Hiroyuki

AU - Akama, Takao

AU - Suzuki, Hiroshi

AU - Yamane, Kazuhide

AU - Kashiwagi, Heihachiro

PY - 1992

Y1 - 1992

N2 - Risk factors for infection were evaluated in patients with active SLE. The active SLE patients complicated by infection within one year after initiation of steroid therapy for SLE (n=19) were compared with those not complicated by infection (n=71) with regard to age, disease duration, laboratory findings, disease activity (SLE Disease Activity Index), and treatment. There was a significant difference in levels of serum albumin, urine protein, serum creatinine, blood urea nitrogen, serum IgA, IgG, and prednisolone dose between the two groups. By using logistic regression analysis, the dependence of infection on the above variables was investigated. The incidence of infection was significantly related to serum albumin level, the severity of SLE (the Healht and Welfare Ministry criteria) and initial prednisolone dose. The severity of SLE, urine protein level, pleural or pericardial effusion, age, and CH 50 were found to contribute in the decreasing order to serum albumin level. We conclude that hypoalbuminemia not only from proteinuria but also from other causes, such as the severity of SLE, may increase the risk of infection in patients with active SLE.

AB - Risk factors for infection were evaluated in patients with active SLE. The active SLE patients complicated by infection within one year after initiation of steroid therapy for SLE (n=19) were compared with those not complicated by infection (n=71) with regard to age, disease duration, laboratory findings, disease activity (SLE Disease Activity Index), and treatment. There was a significant difference in levels of serum albumin, urine protein, serum creatinine, blood urea nitrogen, serum IgA, IgG, and prednisolone dose between the two groups. By using logistic regression analysis, the dependence of infection on the above variables was investigated. The incidence of infection was significantly related to serum albumin level, the severity of SLE (the Healht and Welfare Ministry criteria) and initial prednisolone dose. The severity of SLE, urine protein level, pleural or pericardial effusion, age, and CH 50 were found to contribute in the decreasing order to serum albumin level. We conclude that hypoalbuminemia not only from proteinuria but also from other causes, such as the severity of SLE, may increase the risk of infection in patients with active SLE.

KW - hypoalbimiinemia

KW - infection

KW - risk factor

KW - systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=85004699101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85004699101&partnerID=8YFLogxK

U2 - 10.2177/jsci.15.431

DO - 10.2177/jsci.15.431

M3 - Article

VL - 15

SP - 431

EP - 439

JO - Immunological Medicine

JF - Immunological Medicine

SN - 0911-4300

IS - 5

ER -