RNA Study Using DNA Nanotechnology

Hisashi Tadakuma, Takeya Masubuchi, Takuya Ueda

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transcription is one of the fundamental steps of gene expression, where RNA polymerases (RNAPs) bind to their template genes and make RNAs. In addition to RNAP and the template gene, many molecules such as transcription factors are involved. The interaction and the effect of these factors depend on the geometry. Molecular layout of these factors, RNAP and gene is thus important. DNA nanotechnology is a promising technology that allows controlling of the molecular layout in the range of nanometer to micrometer scale with nanometer resolution; thus, it is expected to expand the RNA study beyond the current limit.

Original languageEnglish
Title of host publicationNanotechnology Tools for the Study of RNA
EditorsSatoko Yoshizawa
PublisherElsevier B.V.
Pages121-163
Number of pages43
ISBN (Print)9780128045657
DOIs
Publication statusPublished - 2016 Jan 1
Externally publishedYes

Publication series

NameProgress in Molecular Biology and Translational Science
Volume139
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Keywords

  • atomic force microscopy (AFM)
  • DNA nanostructure
  • DNA origami
  • RNA polymerase
  • single-molecule imaging

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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  • Cite this

    Tadakuma, H., Masubuchi, T., & Ueda, T. (2016). RNA Study Using DNA Nanotechnology. In S. Yoshizawa (Ed.), Nanotechnology Tools for the Study of RNA (pp. 121-163). (Progress in Molecular Biology and Translational Science; Vol. 139). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2015.11.004