Robustness analysis and optimization of circadian clocks fluctuated by intrinsic noise

Yohei Ito*, Shota Kawachi, Kenko Uchida

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contribution


    Intrinsic noise is a major factor of fluctuations in genetic networks. This paper focuses on circadian clocks as a typical example of oscillatory genetic networks. We analyze fundamental performances of ciracadian clocks that are fluctuated by intrinsic noise, by using two evaluation measures about amplitude fluctuations and period fluctuations that are defined with solutions of the noise covariance matrix equation, which is a periodic Lyapunov differential equation. Based on these two evaluation measures, we also try to optimize a set of parameters that assures more robust performanes of the circadian clocks.

    Original languageEnglish
    Title of host publicationASCC 2011 - 8th Asian Control Conference - Final Program and Proceedings
    Number of pages6
    Publication statusPublished - 2011
    Event8th Asian Control Conference, ASCC 2011 - Kaohsiung
    Duration: 2011 May 152011 May 18


    Other8th Asian Control Conference, ASCC 2011

    ASJC Scopus subject areas

    • Control and Systems Engineering


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