Robustness analysis and optimization of circadian clocks fluctuated by intrinsic noise

Yohei Ito; Shota Kawachi; Kenko Uchida

Robustness analysis and optimization of circadian clocks fluctuated by intrinsic noise

Yohei Ito, Shota Kawachi, Kenko Uchida

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Intrinsic noise is a major factor of fluctuations in genetic networks. This paper focuses on circadian clocks as a typical example of oscillatory genetic networks. We analyze fundamental performances of ciracadian clocks that are fluctuated by intrinsic noise, by using two evaluation measures about amplitude fluctuations and period fluctuations that are defined with solutions of the noise covariance matrix equation, which is a periodic Lyapunov differential equation. Based on these two evaluation measures, we also try to optimize a set of parameters that assures more robust performanes of the circadian clocks.

Original language	English
Title of host publication	ASCC 2011 - 8th Asian Control Conference - Final Program and Proceedings
Pages	506-511
Number of pages	6
Publication status	Published - 2011
Event	8th Asian Control Conference, ASCC 2011 - Kaohsiung Duration: 2011 May 15 → 2011 May 18

Other

Other	8th Asian Control Conference, ASCC 2011
City	Kaohsiung
Period	11/5/15 → 11/5/18

ASJC Scopus subject areas

Control and Systems Engineering

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title = "Robustness analysis and optimization of circadian clocks fluctuated by intrinsic noise",

abstract = "Intrinsic noise is a major factor of fluctuations in genetic networks. This paper focuses on circadian clocks as a typical example of oscillatory genetic networks. We analyze fundamental performances of ciracadian clocks that are fluctuated by intrinsic noise, by using two evaluation measures about amplitude fluctuations and period fluctuations that are defined with solutions of the noise covariance matrix equation, which is a periodic Lyapunov differential equation. Based on these two evaluation measures, we also try to optimize a set of parameters that assures more robust performanes of the circadian clocks.",

author = "Yohei Ito and Shota Kawachi and Kenko Uchida",

year = "2011",

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note = "8th Asian Control Conference, ASCC 2011 ; Conference date: 15-05-2011 Through 18-05-2011",

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AU - Kawachi, Shota

AU - Uchida, Kenko

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N2 - Intrinsic noise is a major factor of fluctuations in genetic networks. This paper focuses on circadian clocks as a typical example of oscillatory genetic networks. We analyze fundamental performances of ciracadian clocks that are fluctuated by intrinsic noise, by using two evaluation measures about amplitude fluctuations and period fluctuations that are defined with solutions of the noise covariance matrix equation, which is a periodic Lyapunov differential equation. Based on these two evaluation measures, we also try to optimize a set of parameters that assures more robust performanes of the circadian clocks.

AB - Intrinsic noise is a major factor of fluctuations in genetic networks. This paper focuses on circadian clocks as a typical example of oscillatory genetic networks. We analyze fundamental performances of ciracadian clocks that are fluctuated by intrinsic noise, by using two evaluation measures about amplitude fluctuations and period fluctuations that are defined with solutions of the noise covariance matrix equation, which is a periodic Lyapunov differential equation. Based on these two evaluation measures, we also try to optimize a set of parameters that assures more robust performanes of the circadian clocks.

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M3 - Conference contribution

AN - SCOPUS:80052002473

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EP - 511

BT - ASCC 2011 - 8th Asian Control Conference - Final Program and Proceedings

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Y2 - 15 May 2011 through 18 May 2011

ER -