Role of cyclin-dependent kinase 5 in capsaicin-induced cough

Junzo Kamei, Shun suke Hayashi, Yoshiki Takahashi, Chihiro Nozaki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The role of cyclin-dependent kinase 5 (Cdk5) in the capsaicin-induced cough reflex was examined in mice. Pretreatment with inhaled roscovitine, a selective Cdk5 inhibitor, at concentrations of 0.3 to 3 mM inhibited the number of capsaicin-induced coughs in a concentration-dependent manner. Pretreatment with inhaled roscovitine, at a concentration of 3 mM also slightly but significantly inhibited the number of citric acid-induced coughs. The number of capsaicin-induced coughs was significantly reduced when C-fibers were desensitized by the pretreatment with capsaicin. The number of citric acid-induced coughs was slightly but significantly reduced in capsaicin-pretreated mice as compared with that in naive mice. Although the inhalation of roscovitine at a concentration of 3 mM significantly reduced the number of citric acid-induced coughs in naive mice to the level observed in capsaicin-pretreated mice, roscovitine had no effect on the number of citric acid-induced coughs in capsaicin-pretreated mice. These results suggest that Cdk5-dependent factors are involved in C-fiber-mediated cough signaling.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalEuropean Journal of Pharmacology
Volume566
Issue number1-3
DOIs
Publication statusPublished - 2007 Jul 2
Externally publishedYes

Keywords

  • Capsaicin
  • Cough reflex
  • Cyclin-dependent kinase 5 (Cdk5)
  • Substance P
  • TRPV1

ASJC Scopus subject areas

  • Pharmacology

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