Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in xenopus embryos

Shoen Kume, Akira Muto, Takafumi Inoue, Kei Suga, Hideyuki Okano, Katsuhiko Mikoshiba

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)

Abstract

The inositol 1,4,5-trisphosphate (IP3) receptor is a calcium ion channel involved in the release of free Ca2+ from intracellular stores. For analysis of the role of IP3-induced Ca2+ release (IICR) on patterning of the embryonic body, monoclonal antibodies that inhibit IICR were produced. Injection of these blocking antibodies into the ventral part of early Xenopus embryos induced modest dorsal differentiation. A close correlation between IICR blocking potencies and ectopic dorsal axis induction frequency suggests that an active IP3-Ca2+ signal may participate in the modulation of ventral differentiation.

Original languageEnglish
Pages (from-to)1940-1943
Number of pages4
JournalScience
Volume278
Issue number5345
DOIs
Publication statusPublished - 1997 Dec 12
Externally publishedYes

ASJC Scopus subject areas

  • General

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