Role of the community effect of cardiomyocyte in the entrainment and reestablishment of stable beating rhythms

Kensuke Kojima, Tomoyuki Kaneko, Kenji Yasuda

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

To investigate the roles that the community effect and entrainment function of cultured cardiomyocyte play in decreasing beating fluctuation and reestablishing synchronized beating, we developed a single-cell-based two-dimensional network culture assay to measure and compare the dynamics of beating rhythm synchronization of individual cells before and after they form networks. Studying the formation of two-cell networks, we found that their synchronized beating tended to be determined by the cardiomyocyte whose beat rate fluctuated less than that of the other cardiomyocyte. We further found that the strength of this tendency increased with the number of cells in the network. These results indicate that (1) beating fluctuation is one of the important factors influencing the reestablishment of a stable synchronous beating rhythm, (2) the larger networks reduce fluctuation, and (3) the formation of a spatial network can itself stabilize cardiomyocyte beat rates.

Original languageEnglish
Pages (from-to)209-215
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume351
Issue number1
DOIs
Publication statusPublished - 2006 Dec 8

Keywords

  • Beating fluctuation
  • Cardiomyocyte
  • Cell network
  • Entrainment
  • Single-cell-based culture assay system
  • Synchronization

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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