Roles of A- and D-type K channels in EPSP integration at a model dendrite

Hiroshi Takagi, Ryo Sato, Masaya Mori, Etsuro Ito, Hideo Suzuki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We examined the roles of A- and D-type K channels in the integration of EPSPs, particularly EPSP reduction, in a model dendrite using a computer simulation program (NEURON), instead of conventional electrophysiological methods which present technical difficulties. We obtained two important results: (1) KD channels play a crucial role in every synaptic input event, and (2) KA channels affect reduction of the second EPSP only when the second synaptic input is applied with a short interval (≤100 ms). These results suggest that KD channels, which have not yet been analyzed experimentally, play a major role in synaptic integration in dendrites by altering their cable properties.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalNeuroscience Letters
Volume254
Issue number3
DOIs
Publication statusPublished - 1998 Oct 2
Externally publishedYes

Fingerprint

Excitatory Postsynaptic Potentials
Dendrites
Computer Simulation
Software

Keywords

  • Cable theory
  • Computer simulation
  • Dendritic Integration
  • K Channels

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Roles of A- and D-type K channels in EPSP integration at a model dendrite. / Takagi, Hiroshi; Sato, Ryo; Mori, Masaya; Ito, Etsuro; Suzuki, Hideo.

In: Neuroscience Letters, Vol. 254, No. 3, 02.10.1998, p. 165-168.

Research output: Contribution to journalArticle

Takagi, Hiroshi ; Sato, Ryo ; Mori, Masaya ; Ito, Etsuro ; Suzuki, Hideo. / Roles of A- and D-type K channels in EPSP integration at a model dendrite. In: Neuroscience Letters. 1998 ; Vol. 254, No. 3. pp. 165-168.
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