Round table on malignant hyperthermia in physically active populations

Meeting proceedings

Yuri Hosokawa, Douglas J. Casa, Henry Rosenberg, John F. Capacchione, Emmanuel Sagui, Sheila Riazi, Luke N. Belval, Patricia A. Deuster, John F. Jardine, Stavros A. Kavouras, Elaine C. Lee, Kevin C. Miller, Sheila M. Muldoon, Francis G. O'connor, Scott R. Sailor, Nyamkhishig Sambuughin, Rebecca L. Stearns, William M. Adams, Robert Huggins, Lesley W. Vandermark

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Context: Recent case reports on malignant hyperthermia (MH)-like syndrome in physically active populations indicate potential associations among MH, exertional heat stroke (EHS), and exertional rhabdomyolysis (ER). However, an expert consensus for clinicians working with these populations is lacking. Objective: To provide current expert consensus on the (1) definition of MH; (2) history, etiology, and pathophysiology of MH; (3) epidemiology of MH; (4) association of MH with EHS and ER; (5) identification of an MH-like syndrome; (6) recommendations for acute management of an MH-like syndrome; (7) special considerations for physically active populations; and (8) future directions for research. Setting: An interassociation task force was formed by experts in athletic training, exercise science, anesthesiology, and emergency medicine. The "Round Table on Malignant Hyperthermia in Physically Active Populations" was convened at the University of Connecticut, Storrs, September 17-18, 2015. Conclusions: Clinicians should consider an MH-like syndrome when a diagnosis of EHS or ER cannot be fully explained by clinical signs and symptoms presented by a patient or when recurrent episodes of EHS or ER (or both) are unexplained. Further research is required to elucidate the genetic and pathophysiological links among MH, EHS, and ER.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalJournal of Athletic Training
Volume52
Issue number4
DOIs
Publication statusPublished - 2017 Apr 1
Externally publishedYes

Fingerprint

Malignant Hyperthermia
Heat Stroke
Rhabdomyolysis
Population
Anesthesiology
Emergency Medicine
Advisory Committees
Research
Signs and Symptoms
Sports
Epidemiology
History
Exercise

Keywords

  • Exertional heat stroke
  • Exertional rhabdomyolysis
  • Ryanodine receptor 1

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hosokawa, Y., Casa, D. J., Rosenberg, H., Capacchione, J. F., Sagui, E., Riazi, S., ... Vandermark, L. W. (2017). Round table on malignant hyperthermia in physically active populations: Meeting proceedings. Journal of Athletic Training, 52(4), 377-383. https://doi.org/10.4085/1062-6050-52.2.06

Round table on malignant hyperthermia in physically active populations : Meeting proceedings. / Hosokawa, Yuri; Casa, Douglas J.; Rosenberg, Henry; Capacchione, John F.; Sagui, Emmanuel; Riazi, Sheila; Belval, Luke N.; Deuster, Patricia A.; Jardine, John F.; Kavouras, Stavros A.; Lee, Elaine C.; Miller, Kevin C.; Muldoon, Sheila M.; O'connor, Francis G.; Sailor, Scott R.; Sambuughin, Nyamkhishig; Stearns, Rebecca L.; Adams, William M.; Huggins, Robert; Vandermark, Lesley W.

In: Journal of Athletic Training, Vol. 52, No. 4, 01.04.2017, p. 377-383.

Research output: Contribution to journalArticle

Hosokawa, Y, Casa, DJ, Rosenberg, H, Capacchione, JF, Sagui, E, Riazi, S, Belval, LN, Deuster, PA, Jardine, JF, Kavouras, SA, Lee, EC, Miller, KC, Muldoon, SM, O'connor, FG, Sailor, SR, Sambuughin, N, Stearns, RL, Adams, WM, Huggins, R & Vandermark, LW 2017, 'Round table on malignant hyperthermia in physically active populations: Meeting proceedings', Journal of Athletic Training, vol. 52, no. 4, pp. 377-383. https://doi.org/10.4085/1062-6050-52.2.06
Hosokawa, Yuri ; Casa, Douglas J. ; Rosenberg, Henry ; Capacchione, John F. ; Sagui, Emmanuel ; Riazi, Sheila ; Belval, Luke N. ; Deuster, Patricia A. ; Jardine, John F. ; Kavouras, Stavros A. ; Lee, Elaine C. ; Miller, Kevin C. ; Muldoon, Sheila M. ; O'connor, Francis G. ; Sailor, Scott R. ; Sambuughin, Nyamkhishig ; Stearns, Rebecca L. ; Adams, William M. ; Huggins, Robert ; Vandermark, Lesley W. / Round table on malignant hyperthermia in physically active populations : Meeting proceedings. In: Journal of Athletic Training. 2017 ; Vol. 52, No. 4. pp. 377-383.
@article{43ef01bf00bf4d4cab55ce9900b399d1,
title = "Round table on malignant hyperthermia in physically active populations: Meeting proceedings",
abstract = "Context: Recent case reports on malignant hyperthermia (MH)-like syndrome in physically active populations indicate potential associations among MH, exertional heat stroke (EHS), and exertional rhabdomyolysis (ER). However, an expert consensus for clinicians working with these populations is lacking. Objective: To provide current expert consensus on the (1) definition of MH; (2) history, etiology, and pathophysiology of MH; (3) epidemiology of MH; (4) association of MH with EHS and ER; (5) identification of an MH-like syndrome; (6) recommendations for acute management of an MH-like syndrome; (7) special considerations for physically active populations; and (8) future directions for research. Setting: An interassociation task force was formed by experts in athletic training, exercise science, anesthesiology, and emergency medicine. The {"}Round Table on Malignant Hyperthermia in Physically Active Populations{"} was convened at the University of Connecticut, Storrs, September 17-18, 2015. Conclusions: Clinicians should consider an MH-like syndrome when a diagnosis of EHS or ER cannot be fully explained by clinical signs and symptoms presented by a patient or when recurrent episodes of EHS or ER (or both) are unexplained. Further research is required to elucidate the genetic and pathophysiological links among MH, EHS, and ER.",
keywords = "Exertional heat stroke, Exertional rhabdomyolysis, Ryanodine receptor 1",
author = "Yuri Hosokawa and Casa, {Douglas J.} and Henry Rosenberg and Capacchione, {John F.} and Emmanuel Sagui and Sheila Riazi and Belval, {Luke N.} and Deuster, {Patricia A.} and Jardine, {John F.} and Kavouras, {Stavros A.} and Lee, {Elaine C.} and Miller, {Kevin C.} and Muldoon, {Sheila M.} and O'connor, {Francis G.} and Sailor, {Scott R.} and Nyamkhishig Sambuughin and Stearns, {Rebecca L.} and Adams, {William M.} and Robert Huggins and Vandermark, {Lesley W.}",
year = "2017",
month = "4",
day = "1",
doi = "10.4085/1062-6050-52.2.06",
language = "English",
volume = "52",
pages = "377--383",
journal = "Journal of Athletic Training",
issn = "1062-6050",
publisher = "National Athletic Trainers' Association Inc.",
number = "4",

}

TY - JOUR

T1 - Round table on malignant hyperthermia in physically active populations

T2 - Meeting proceedings

AU - Hosokawa, Yuri

AU - Casa, Douglas J.

AU - Rosenberg, Henry

AU - Capacchione, John F.

AU - Sagui, Emmanuel

AU - Riazi, Sheila

AU - Belval, Luke N.

AU - Deuster, Patricia A.

AU - Jardine, John F.

AU - Kavouras, Stavros A.

AU - Lee, Elaine C.

AU - Miller, Kevin C.

AU - Muldoon, Sheila M.

AU - O'connor, Francis G.

AU - Sailor, Scott R.

AU - Sambuughin, Nyamkhishig

AU - Stearns, Rebecca L.

AU - Adams, William M.

AU - Huggins, Robert

AU - Vandermark, Lesley W.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Context: Recent case reports on malignant hyperthermia (MH)-like syndrome in physically active populations indicate potential associations among MH, exertional heat stroke (EHS), and exertional rhabdomyolysis (ER). However, an expert consensus for clinicians working with these populations is lacking. Objective: To provide current expert consensus on the (1) definition of MH; (2) history, etiology, and pathophysiology of MH; (3) epidemiology of MH; (4) association of MH with EHS and ER; (5) identification of an MH-like syndrome; (6) recommendations for acute management of an MH-like syndrome; (7) special considerations for physically active populations; and (8) future directions for research. Setting: An interassociation task force was formed by experts in athletic training, exercise science, anesthesiology, and emergency medicine. The "Round Table on Malignant Hyperthermia in Physically Active Populations" was convened at the University of Connecticut, Storrs, September 17-18, 2015. Conclusions: Clinicians should consider an MH-like syndrome when a diagnosis of EHS or ER cannot be fully explained by clinical signs and symptoms presented by a patient or when recurrent episodes of EHS or ER (or both) are unexplained. Further research is required to elucidate the genetic and pathophysiological links among MH, EHS, and ER.

AB - Context: Recent case reports on malignant hyperthermia (MH)-like syndrome in physically active populations indicate potential associations among MH, exertional heat stroke (EHS), and exertional rhabdomyolysis (ER). However, an expert consensus for clinicians working with these populations is lacking. Objective: To provide current expert consensus on the (1) definition of MH; (2) history, etiology, and pathophysiology of MH; (3) epidemiology of MH; (4) association of MH with EHS and ER; (5) identification of an MH-like syndrome; (6) recommendations for acute management of an MH-like syndrome; (7) special considerations for physically active populations; and (8) future directions for research. Setting: An interassociation task force was formed by experts in athletic training, exercise science, anesthesiology, and emergency medicine. The "Round Table on Malignant Hyperthermia in Physically Active Populations" was convened at the University of Connecticut, Storrs, September 17-18, 2015. Conclusions: Clinicians should consider an MH-like syndrome when a diagnosis of EHS or ER cannot be fully explained by clinical signs and symptoms presented by a patient or when recurrent episodes of EHS or ER (or both) are unexplained. Further research is required to elucidate the genetic and pathophysiological links among MH, EHS, and ER.

KW - Exertional heat stroke

KW - Exertional rhabdomyolysis

KW - Ryanodine receptor 1

UR - http://www.scopus.com/inward/record.url?scp=85018803256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018803256&partnerID=8YFLogxK

U2 - 10.4085/1062-6050-52.2.06

DO - 10.4085/1062-6050-52.2.06

M3 - Article

VL - 52

SP - 377

EP - 383

JO - Journal of Athletic Training

JF - Journal of Athletic Training

SN - 1062-6050

IS - 4

ER -