Sattahipmycin, a Hexacyclic Xanthone Produced by a Marine-Derived Streptomyces

Kantinan Leetanasaksakul, Wilaiwan Koomsiri, Takuya Suga, Hirotaka Matsuo, Rei Hokari, Pakorn Wattana-Amorn, Yō Ko Takahashi, Kazuro Shiomi, Takuji Nakashima, Yuki Inahashi, Arinthip Thamchaipenet*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Sattahipmycin was isolated from the mycelium of marine-derived Streptomyces sp. GKU 257-1 by following the antibiofilm activity against E. coli NBRC 3972 throughout the purification steps. The structure of sattahipmycin was determined to be a new polycyclic xanthone related to xantholipin but lacking a dioxymethylene and a chlorinated carbon. This compound showed activity toward Gram-positive bacteria and Plasmodium falciparum, antibiofilm formation of Escherichia coli, and cytotoxicity to human cancer cell lines. Using genome sequence data, a biosynthetic pathway leading to sattahipmycin has been proposed involving an uncharacterized type II polyketide synthase biosynthetic gene cluster.

Original languageEnglish
Pages (from-to)1211-1217
Number of pages7
JournalJournal of Natural Products
Volume85
Issue number5
DOIs
Publication statusPublished - 2022 May 27
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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