Schema-dependent gene activation and memory encoding in neocortex

Dorothy Tse, Tomonori Takeuchi, Masaki Kakeyama, Yasushi Kajii, Hiroyuki Okuno, Chiharu Tohyama, Haruhiko Bito, Richard G M Morris

Research output: Contribution to journalArticle

265 Citations (Scopus)

Abstract

When new learning occurs against the background of established prior knowledge, relevant new information can be assimilated into a schema and thereby expand the knowledge base. An animal model of this important component of memory consolidation reveals that systems memory consolidation can be very fast. In experiments with rats, we found that the hippocampal-dependent learning of new paired associates is associated with a striking up-regulation of immediate early genes in the prelimbic region of the medial prefrontal cortex, and that pharmacological interventions targeted at that area can prevent both new learning and the recall of remotely and even recently consolidated information. These findings challenge the concept of distinct fast (hippocampal) and slow (cortical) learning systems, and shed new light on the neural mechanisms of memory assimilation into schemas.

Original languageEnglish
Pages (from-to)891-895
Number of pages5
JournalScience
Volume333
Issue number6044
DOIs
Publication statusPublished - 2011 Aug 12
Externally publishedYes

Fingerprint

Neocortex
Transcriptional Activation
Learning
Paired-Associate Learning
Immediate-Early Genes
Knowledge Bases
Prefrontal Cortex
Up-Regulation
Animal Models
Pharmacology
Memory Consolidation

ASJC Scopus subject areas

  • General

Cite this

Tse, D., Takeuchi, T., Kakeyama, M., Kajii, Y., Okuno, H., Tohyama, C., ... Morris, R. G. M. (2011). Schema-dependent gene activation and memory encoding in neocortex. Science, 333(6044), 891-895. https://doi.org/10.1126/science.1205274

Schema-dependent gene activation and memory encoding in neocortex. / Tse, Dorothy; Takeuchi, Tomonori; Kakeyama, Masaki; Kajii, Yasushi; Okuno, Hiroyuki; Tohyama, Chiharu; Bito, Haruhiko; Morris, Richard G M.

In: Science, Vol. 333, No. 6044, 12.08.2011, p. 891-895.

Research output: Contribution to journalArticle

Tse, D, Takeuchi, T, Kakeyama, M, Kajii, Y, Okuno, H, Tohyama, C, Bito, H & Morris, RGM 2011, 'Schema-dependent gene activation and memory encoding in neocortex', Science, vol. 333, no. 6044, pp. 891-895. https://doi.org/10.1126/science.1205274
Tse D, Takeuchi T, Kakeyama M, Kajii Y, Okuno H, Tohyama C et al. Schema-dependent gene activation and memory encoding in neocortex. Science. 2011 Aug 12;333(6044):891-895. https://doi.org/10.1126/science.1205274
Tse, Dorothy ; Takeuchi, Tomonori ; Kakeyama, Masaki ; Kajii, Yasushi ; Okuno, Hiroyuki ; Tohyama, Chiharu ; Bito, Haruhiko ; Morris, Richard G M. / Schema-dependent gene activation and memory encoding in neocortex. In: Science. 2011 ; Vol. 333, No. 6044. pp. 891-895.
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