Schemas and memory consolidation

Dorothy Tse, Rosamund F. Langston, Masaki Kakeyama, Ingrid Bethus, Patrick A. Spooner, Emma R. Wood, Menno P. Witter, Richard G M Morris

Research output: Contribution to journalArticle

577 Citations (Scopus)

Abstract

Memory encoding occurs rapidly, but the consolidation of memory in the neocortex has long been held to be a more gradual process. We now report, however, that systems consolidation can occur extremely quickly if an associative "schema" into which new information is incorporated has previously been created. In experiments using a hippocampal-dependent paired-associate task for rats, the memory of flavor-place associations became persistent over time as a putative neocortkal schema gradually developed. New traces, trained for only one trial, then became assimilated and rapidly hippocampal-independent. Schemas also played a causal role in the creation of lasting associative memory representations during one-trial learning. The concept of neocortkal schemas may unite psychological accounts of knowledge structures with neurobiological theories of systems memory consolidation.

Original languageEnglish
Pages (from-to)76-82
Number of pages7
JournalScience
Volume316
Issue number5821
DOIs
Publication statusPublished - 2007 Apr 6
Externally publishedYes

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ASJC Scopus subject areas

  • General

Cite this

Tse, D., Langston, R. F., Kakeyama, M., Bethus, I., Spooner, P. A., Wood, E. R., Witter, M. P., & Morris, R. G. M. (2007). Schemas and memory consolidation. Science, 316(5821), 76-82. https://doi.org/10.1126/science.1135935