Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei

Kentaro Takada; Taisuke Uehara; Yoichi Nakao; Shigeki Matsunaga; Rob W.M. Van Soest; Nobuhiro Fusetani

Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei

Kentaro Takada, Taisuke Uehara, Yoichi Nakao, Shigeki Matsunaga, Rob W.M. Van Soest, Nobuhiro Fusetani^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

Abstract

Three new α-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradations to be the isoquinoline alkaloids, encompassing two amino acids, and C₂₈ fatty acid, the last of which was sulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosher analysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit α-glucosidase with IC₅₀ values of 48-170 nM.

Original language	English
Pages (from-to)	187-193
Number of pages	7
Journal	Journal of the American Chemical Society
Volume	126
Issue number	1
Publication status	Published - 2004 Jan 14
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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AU - Takada, Kentaro

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AU - Nakao, Yoichi

AU - Matsunaga, Shigeki

AU - Van Soest, Rob W.M.

AU - Fusetani, Nobuhiro

PY - 2004/1/14

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AB - Three new α-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradations to be the isoquinoline alkaloids, encompassing two amino acids, and C28 fatty acid, the last of which was sulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosher analysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit α-glucosidase with IC50 values of 48-170 nM.

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Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei

Abstract

ASJC Scopus subject areas

UN SDGs

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