Screening for sulfur compounds by molybdenum-catalyzed oxidation combined with liquid chromatography-mass spectrometry

Hirotaka Matsuo, Yu Hanamure, Rei Miyano, Yōko Takahashi, Satoshi Ōmura, Takuji Nakashima

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The molybdenum (Mo)-catalyzed oxidation of sulfide under neutral conditions yields sulfone. This reaction proceeds more smoothly than olefin epoxidation and primary or secondary alcohol oxidation. In this study, Mo-catalyzed oxidation was used to screen for sulfur compounds (named “MoS-screening”) in microbial broths by liquid chromatography-mass spectrometry (LC/MS). To demonstrate proof-of-concept, known sulfur microbial compounds were successfully identified from a mixture of non-sulfur microbial compounds as sulfinyl or sulfonyl products of Mo-catalyzed oxidation. Then our MoS-screening method was used to screen 300 samples of microbial broth for sulfur compounds. One of the identified compounds was a kitasetaline-containing N-acetyl cysteine moiety produced by an actinomycete strain. These results demonstrate the potential of MoS-screening in the search for new sulfur compounds from microbial sources.

Original languageEnglish
Article number240
JournalMolecules
Volume25
Issue number2
DOIs
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Microbial metabolites
  • Molybdenum-catalyzed oxidation
  • MoS-screening
  • Screening method
  • Sulfoxidation
  • Sulfur compounds

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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