Seasonal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts

Shogo Haraguchi, Masahiro Matsunaga, Teppei Koyama, Jean Luc Do Rego, Kazuyoshi Tsutsui

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    10 Citations (Scopus)

    Abstract

    We recently found that the newt brain actively produces 7α-hydroxypregnenolone, a novel amphibian neurosteroid stimulating locomotor activity. It is well known that locomotor activity of male newts increases during the breeding period. To understand the physiological role of 7α-hydroxypregnenolone, we investigated seasonal changes in 7α-hydroxypregnenolone synthesis in the brain of male newts. Interestingly, 7α-hydroxypregnenolone synthesis in the brain showed marked changes during the annual breeding cycle, with a maximal level in the breeding period when locomotor activity of male newts increases. These results suggest that 7α-hydroxypregnenolone induces seasonal locomotor changes in male newts.

    Original languageEnglish
    Title of host publicationAnnals of the New York Academy of Sciences
    Pages410-413
    Number of pages4
    Volume1163
    DOIs
    Publication statusPublished - 2009 Apr

    Publication series

    NameAnnals of the New York Academy of Sciences
    Volume1163
    ISSN (Print)00778923
    ISSN (Electronic)17496632

    Fingerprint

    Salamandridae
    Locomotion
    Neurotransmitter Agents
    Breeding
    Brain
    Amphibians
    7-hydroxypregnenolone

    Keywords

    • 7α-hydroxypregnenolone
    • Locomotor activity
    • Neurosteroids
    • Newts
    • Seasonal changes

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Haraguchi, S., Matsunaga, M., Koyama, T., Rego, J. L. D., & Tsutsui, K. (2009). Seasonal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts. In Annals of the New York Academy of Sciences (Vol. 1163, pp. 410-413). (Annals of the New York Academy of Sciences; Vol. 1163). https://doi.org/10.1111/j.1749-6632.2008.03621.x

    Seasonal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts. / Haraguchi, Shogo; Matsunaga, Masahiro; Koyama, Teppei; Rego, Jean Luc Do; Tsutsui, Kazuyoshi.

    Annals of the New York Academy of Sciences. Vol. 1163 2009. p. 410-413 (Annals of the New York Academy of Sciences; Vol. 1163).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Haraguchi, S, Matsunaga, M, Koyama, T, Rego, JLD & Tsutsui, K 2009, Seasonal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts. in Annals of the New York Academy of Sciences. vol. 1163, Annals of the New York Academy of Sciences, vol. 1163, pp. 410-413. https://doi.org/10.1111/j.1749-6632.2008.03621.x
    Haraguchi S, Matsunaga M, Koyama T, Rego JLD, Tsutsui K. Seasonal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts. In Annals of the New York Academy of Sciences. Vol. 1163. 2009. p. 410-413. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2008.03621.x
    Haraguchi, Shogo ; Matsunaga, Masahiro ; Koyama, Teppei ; Rego, Jean Luc Do ; Tsutsui, Kazuyoshi. / Seasonal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts. Annals of the New York Academy of Sciences. Vol. 1163 2009. pp. 410-413 (Annals of the New York Academy of Sciences).
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