Sedentary behavior is associated with reduced cardiovagal baroreflex sensitivity in healthy adults

Shoya Mori, Keisei Kosaki, Masahiro Matsui, Kanako Takahashi, Masaki Yoshioka, Takashi Tarumi, Jun Sugawara, Ai Shibata, Makoto Kuro-O, Chie Saito, Kunihiro Yamagata, Koichiro Oka, Seiji Maeda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Sedentary behavior is an established risk factor for cardiovascular disease; however, it remains unclear whether sedentary behavior is associated with the deterioration of arterial blood pressure regulation. The purpose of this study was to determine the association between the time spent in sedentary behavior and cardiovagal baroreflex sensitivity (cBRS) in healthy adults. We investigated the cross-sectional relationship between sedentary time and cBRS in 179 adults aged 22–81 years. Sedentary time was objectively measured using a triaxial accelerometer. cBRS was evaluated by the transfer function gain of beat-by-beat changes in systolic blood pressure and the R-R interval during 5 min of spontaneous resting. Glycemic, lipidemic, and vascular risk factors were measured as potential covariates of cBRS and sedentary behavior. Men had a longer sedentary time and lower cBRS than women (p = 0.001). In a simple correlation analysis, older age was negatively associated with cBRS and positively associated with sedentary time, but sedentary time was not correlated with cBRS. However, after adjustment for age and sex, a longer sedentary time was associated with a lower cBRS. Multiple linear regression analysis showed that sedentary time was independently associated with lower cBRS with adjustment for covariates (β = −0.325, p = 0.002). A significant association was also confirmed when the analysis was performed separately in the younger and older groups. This finding suggests that high sedentary behavior may have an adverse effect on arterial blood pressure regulation.

Original languageEnglish
Pages (from-to)1193-1202
Number of pages10
JournalHypertension Research
Issue number7
Publication statusPublished - 2022 Jul


  • Accelerometer
  • Arterial baroreflex
  • Blood pressure regulation
  • Cardiovascular disease
  • Sedentary behavior
  • Transfer function analysis

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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